蛋白泛素化修饰在肠道炎症反应发生发展中的调控作用  

The regulation role of protein ubiquitination in the development and progression of intestinal inflammation

作　　者：汪朝辉 姚玲雅 张舟 张瑜[1,2] 曹倩[1,2] Wang Chaohui;Yao Lingya;Zhang Zhou;Zhang Yu;Cao Qian(Department of Gastroenterology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China;Inflammatory Bowel Disease Center,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院消化内科,杭州310016 [2]浙江大学医学院附属邵逸夫医院炎症性肠病中心,杭州310016

出　　处：《中华炎性肠病杂志（中英文）》2021年第2期178-182,共5页Chinese Journal of Inflammatory Bowel Diseases

基　　金：浙江省自然科学基金(LQ19H030014)。

摘　　要：肠道炎症反应的致病因素多样,但活化的免疫应答过程是相似的。泛素化修饰是细胞内广泛存在的蛋白质翻译后修饰机制,其在信号传导、转录调节、蛋白激酶活化过程中起着调节功能。免疫炎症信号通路相关蛋白的泛素化修饰决定了炎性介质和抗炎因子之间的平衡,从而影响肠道炎症的进展与转归。本文综述了蛋白泛素化修饰过程,有助于加深对肠道炎症病理生理过程的理解,并为精准治疗中相关靶向新药的研发提供理论参考。There are diverse pathogenic factors for intestinal inflammation,but the process of activated immune response is similar.Ubiquitination,a widespread mechanism of protein post-translational modification in cells,plays a regulatory role in signal transduction,transcriptional regulation and protein kinase activation.Ubiquitination of proteins involving in immune inflammation signaling pathways determines the balance between inflammatory mediators and anti-inflammatory factors,thus affects the progression and outcome of intestinal inflammation.This article reviews the ubiquitination modification of protein,which will help to deeply understand the pathophysiological process of intestinal inflammation,and provide a theoretical reference for the research and development of targeted new drugs in precision therapy.

关 键 词：肠道炎症 泛素化 去泛素化 免疫反应 固有免疫 特异性免疫 细胞因子类 

分 类 号：R574[医药卫生—消化系统]