B、T淋巴细胞弱化因子在免疫性疾病中的研究进展  

Research progress of B and T lymphocyte attenuator in immune diseases

作　　者：符力升 许昱[1] Fu Lisheng;Xu Yu(Department of Otolaryngology Head and Neck Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院耳鼻咽喉头颈外科,430060

出　　处：《中华微生物学和免疫学杂志》2021年第5期406-410,共5页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金(81770986)。

摘　　要：B、T淋巴细胞弱化因子(B and T lymphocyte attenuator, BTLA)是21世纪初发现的负向共刺激分子成员,是Ig超家族的Ⅰ型跨膜蛋白,其配体为肿瘤坏死因子超家族的疱疹病毒侵入介体(herpesvirus entry mediator, HVEM)。BTLA调节γδT细胞和固有淋巴细胞(ILCs)稳态,促进效应T细胞存活,并帮助其向记忆T细胞分化;BTLA还在维持树突状细胞(DCs)稳态中发挥着重要作用;有研究表明BTLA敲除的小鼠对自身免疫性疾病的易感性增加。近年来的研究表明,BTLA在过敏性疾病(如过敏性结膜炎、过敏性鼻炎)和自身免疫性疾病(如系统性红斑狼疮、强直性脊柱炎)中可发挥重要作用。本文对BTLA在免疫性疾病中的研究进展做出系统的综述。B and T lymphocyte attenuator(BTLA)is an immune checkpoint discovered in the early 21st century.BTLA is a typeⅠtransmembrane protein that belongs to Ig super family.The ligand for BTLA is herpesvirus-entry mediator(HVEM),a TNF receptor family protein.BTLA regulates the homeostasis ofγδT cells and innate lymphocytes(ILCs),promotes the survival of effector T cells and helps them differentiate into memory T cells.BTLA also plays an important role in maintaining the homeostasis of dendritic cells(DCs).Studies have shown that BTLA knockout mice have increased susceptibility to autoimmune diseases.Recent studies showed that BTLA also plays a crucial role in allergic diseases(such as allergic conjunctivitis and allergic rhinitis)and autoimmune diseases(such as systemic lupus erythematosus and ankylosing spondylitis).This article makes a systematic review about recent researches of BTLA in immune diseases.

关 键 词：免疫抑制分子 BTLA HVEM 过敏性疾病 自身免疫性疾病 

分 类 号：R593[医药卫生—内科学]