鼻咽癌组织COX-2、SDHB、HSP90β表达与临床病理特征及预后的关系研究  

Study on the Relationship between the Expression of COX-2, SDHB and HSP90β and the Clinicopathological Characteristics and Prognosis of Nasopharyngeal Carcinoma

作　　者：刘英香 王丽辉 李晓惠 韦喜生 唐育群 郑晓君 LIU Ying-xiang;WANGLi-hui;LI Xiao-hui;WEI Xi-sheng;TANG Yu-qun;ZHENG Xiao-jun(Department of Oncology,74th Army Hospital of Chinese People's Liberation Army,Guangzhou,Guangdong,510320,China;Department of Rehabilitation Medicine,Pudong Hospital Affiliated to Fudan University,Shanghai,200120,China)

机构地区：[1]中国人民解放军陆军第七十四集团军医院肿瘤科,广东广州510320 [2]复旦大学附属浦东医院康复医学科,上海200120

出　　处：《现代生物医学进展》2021年第10期1921-1925,共5页Progress in Modern Biomedicine

基　　金：广东省自然科学基金项目(2014A030313780)。

摘　　要：目的:探讨鼻咽癌组织环氧化酶-2(COX-2)、琥珀酸脱氢酶(SDHB)、热休克蛋白90β(HSP90β)表达与临床病理特征及预后的关系.方法:应用免疫组织化学染色法对78例鼻咽癌组织和65例鼻咽部慢性炎症组织中COX-2、SDHB、HSP90β表达情况进行检测,并分析鼻咽癌组织中COX-2、SDHB、HSP90β表达与临床病理特征的关系及其相关性.所有患者随访3年,根据不同COX-2、SDHB、HSP90β表达情况将患者分为COX-2阳性组、COX-2阴性组、SDHB阳性组、SDHB阴性组、HSP90β阳性组、HSP90β阴性组,比较各组患者生存情况.结果:鼻咽癌组织中COX-2、HSP90β阳性率显著高于鼻咽部慢性炎症组织,SDHB阳性率显著低于鼻咽部慢性炎症组织(P<0.05).TNM分期为Ⅲ+Ⅳ期、中低分化、有颈淋巴结转移者鼻咽癌组织中COX-2、HSP90β阳性率显著高于TNM分期为Ⅰ+Ⅱ期、高分化、无颈淋巴结转移者,SDHB阳性率显著低于TNM分期为Ⅰ+Ⅱ期、高分化、无颈淋巴结转移者(P<0.05).Spearman相关分析显示,鼻咽癌组织中COX-2表达与SDHB表达呈负相关(rs=-0.462,P=0.008),与HSP90β表达呈正相关(rs=0.501,P=0.000),HSP90β表达与SDHB表达呈负相关(rs=-0.438,P=0.012).随访3年,存活49例,死亡29例,存活率62.82%.鼻咽癌组织COX-2阴性组、SDHB阳性组、HSP90β阴性组患者生存率、中位生存期显著优于COX-2阳性组、SDHB阴性组、HSP90β阳性组患者(P<0.05).结论:鼻咽癌组织中COX-2、SDHB、HSP90β表达情况与患者TNM分期、肿瘤分化情况和颈淋巴结转移相关,且其表达情况与鼻咽癌患者生存期有密切关系.Objective:To investigate the relationship between the expression of cyclooxygenase-2(COX-2),succinate dehydrogenase(SDHB),heat shock protein 90β(HSP90β)and the clinicopathological characteristics and prognosis of nasopharyngeal carcinoma.Methods:The expression of COX-2,SDHB and HSP90βin 78 cases of nasopharyngeal carcinoma tissue and 65 cases of chronic inflammation of nasopharynx were detected by immunohistochemistry,and the relationship between the expression of COX-2,SDHB and HSP90βand the clinicopathological characteristics of NPC was analyzed.All patients were followed up for 3 years.According to the expression of COX-2,SDHB and HSP90β,the patients were divided into COX-2 positive group,COX-2 negative group,SDHB positive group,SDHB negative group,HSP90βpositive group and HSP90βnegative group.Results:The positive rate of COX-2 and HSP90βin nasopharyngeal carcinoma tissue was significantly higher than that in nasopharynx,and the positive rate of SDHB was significantly lower than that in nasopharynx(P<0.05).The positive rates of COX-2 and HSP90βin nasopharyngeal carcinoma tissue with TNM stage III+IV,middle and low differentiation and cervical lymph node metastasis were significantly higher than those TNM stage I+II,high differentiation and no cervical lymph node metastasis,and the positive rates of SDHB were significantly lower than those in nasopharyngeal carcinoma tissue with TNM stage I+II,high differentiation and no cervical lymph node metastasis(P<0.05).Spearman correlation analysis showed that COX-2 expression was negatively correlated with SDHB expression(rs=-0.462,P=0.008),positively correlated with HSP90βexpression(rs=0.501,P=0.000),and SDHB was negatively correlated with HSP90βexpression(rs=-0.438,P=0.012).After 3 years follow-up,49 cases survived and 29 died,with a survival rate of 62.82%.The survival rate and median survival time of patients in COX-2 negative group,SDHB positive group and HSP90βnegative group were significantly better than those in COX-2 positive group,SDHB negative gro

关 键 词：鼻咽癌 环氧化酶-2 琥珀酸脱氢酶 热休克蛋白90β 临床病理特征 预后 

分 类 号：R739.6[医药卫生—肿瘤]