吗替麦考酚酯的合成新工艺  

New process for preparation of mycophenolate mofetil

作　　者：马驰 黄杨威 赵学清[2] 林羽[1] 徐伟[1] MA Chi;HUANG Yangwei;ZHAO Xueqing;LIN Yu;XU Wei(Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Fujian Institute of Microbiology,Fuzhou 350007,China)

机构地区：[1]福建中医药大学药学院,福建福州350122 [2]福建省微生物研究所,福建福州350007

出　　处：《药学研究》2021年第5期310-311,共2页Journal of Pharmaceutical Research

基　　金：福建省公益类科研院所基本科研专项(No.2015R1009-5)。

摘　　要：目的开发吗替麦考酚酯合成新工艺。方法由麦考酚酸与N-羟乙基吗啉经Mitsunobu反应制备。结果收率为81%,产品质量符合《中国药典》2020年版。结论该方法反应条件温和、工艺简易、绿色、高收率。Objective To develop a new process for preparation of mycophenolate mofetil.Methods Via Mitsunobu reaction from N-hydroxyethylmorpholine and mycophenolic acid.Results The high yield(81%)and good quality complying with the Pharmacopoeia of the People′s Republic of China(2020th).Conclusion A green and highly efficient process with its mild reaction conditions and simple work-procedures.

关 键 词：吗替麦考酚酯 羟乙基吗啉 麦考酚酸 MITSUNOBU反应 

分 类 号：R914.5[医药卫生—药物化学]