血管性痴呆模型及信号通路研究进展  

Research progress on model and signaling pathways of vascular dementia

作　　者：王玺宁 陈真[1] WANG Xining;CHEN Zhen(China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学,江苏南京211198

出　　处：《药学研究》2021年第5期329-333,共5页Journal of Pharmaceutical Research

摘　　要：血管性痴呆是指由缺血性卒中、出血性卒中和造成脑区低灌注的脑血管疾病所致的严重认知功能障碍综合征。血管性痴呆是可以预防的,因为针对致病性脑血管疾病已建立了例如控制血管危险因素、抗血小板治疗和抗凝治疗等预防措施,然而目前尚无针对血管性痴呆的对症治疗方法。了解其基本机制及模型对于血管性痴呆的治疗至关重要。本文简述了血管性痴呆的多种动物模型,并简要介绍了目前针对其发病机制的相关通路研究,为血管性痴呆的治疗和用药提供参考。Vascular dementia is a severe cognitive impairment syndrome caused by ischemic stroke,hemorrhagic stroke and cerebrovascular disease causing hypoperfusion in the brain region.Vascular dementia can be prevented because preventive measures such as control of vascular risk factors,antiplatelet therapy and anticoagulation therapy have been established for pathogenic cerebrovascular diseases,but there is no symptomatic treatment for vascular dementia.Understanding its basic mechanism and model is very important for the treatment of vascular dementia.This article describes some animal models of vascular dementia,and briefly introduces current research on its pathogenesis,providing a reference for the treatment and medication of vascular dementia.

关 键 词：血管性痴呆 模型研究 信号通路 

分 类 号：R749.13[医药卫生—神经病学与精神病学]