蚌埠地区医师高血压处方行为和影响因素调查及典型相关分析  

Investigation and Canonical Correlation Analysis of Doctors’Hypertension Prescription Behavior and Influencing Factors in the Bengbu Area

作　　者：叶根深[1,2,3] 王蕾 杨阳[1] 吴珊珊[1] 马静 忻志鸣[1,2,3] YE Genshen;WANG Lei;YANG Yang;WU Shanshan;MA Jing;XIN Zhiming(Bengbu First People’s Hospital,Anhui,China 233000;Bengbu Pharmaceutical Affairs Management Quality Control Center,Anhui,China 233000;Clinical Pharmaceutical Branch of Bengbu Medical Association,Anhui,China 233000)

机构地区：[1]安徽省蚌埠市第一人民医院,安徽蚌埠233000 [2]安徽省蚌埠市药事管理专业质量控制中心,安徽蚌埠233000 [3]安徽省蚌埠市医学会临床药学分会,安徽蚌埠233000

出　　处：《中国药业》2021年第11期19-24,共6页China Pharmaceuticals

基　　金：安徽省蚌埠市科技指导项目[蚌科[2016]20号]。

摘　　要：目的探讨蚌埠地区医师高血压处方行为与影响因素。方法现场向蚌埠地区医疗机构的医务人员发放匿名调查问卷,内容包括医师高血压处方行为和影响因素两大类。结果共纳入问卷312份。经秩变换LSD单因素方差分析,医师遴选降压药偏好为血管紧张素转换酶抑制剂、血管紧张素受体拮抗剂(A类)>钙拮抗剂(C类)>利尿剂(D类)≈β受体阻滞剂(B类)>复方制剂;超说明书用药行为中,"没有""偶尔有""经常有""不清楚"的依次为191例(61.22%)、90例(28.85%)、14例(4.49%)、17例(5.45%);经典型相关分析,医师工作年限和学历、患者经济条件、本院有无该药品对临床遴选药物(特别是A类和C类)影响更大;超说明书用药行为系综合因素引起。结论蚌埠地区医师更偏好遴选A类和C类降压药,有必要采取综合措施促进遴选复方制剂,改善医师超说明书应用降压药行为。Objective To investigate the doctors’hypertension prescription behavior and influencing factors in the Bengbu area.Methods An on-site anonymous survey was conducted among the medical staff in the medical institutions in Bengbu area by questionnaires,which included two categories:doctors’prescription behavior and influencing factors.Results A total of 312 questionnaires were included.Rank transformation followed by LSD one-way analysis of variance(ANOVA)results showed that doctors’preference for antihypertensive drugs was as follows:angiotensin-converting enzyme inhibitors,angiotensin receptor antagonists(class A)>calcium antagonists(class C)>diuretics(class D)≈βreceptor blockers(class B)>compound preparations.For the behaviors of off-label drug use,″no″″occasionally″″often″and″unclear″were orderly 191 cases(61.22%),90 cases(28.85%),14 cases(4.49%),and 17 cases(5.45%).Canonical correlation analysis results showed that the doctors’working years and educational background,the patients’economic conditions,and hospital drug availability influenced more on the clinical selection of drugs(especially class A and class C).Off-label drug use behavior was caused by comprehensive factors.Conclusion Doctors in the Bengbu area prefer to select class A and class C antihypertensive drugs.It’s necessary to take comprehensive measures to promote the selection of compound preparations and improve doctors’behavior of off-label use for anti-hypertensive drugs.

关 键 词：医师 高血压 处方行为 影响因素 超说明书用药 典型相关分析 问卷调查 蚌埠地区 

分 类 号：R954[医药卫生—药学] R972.4