同时性多原发肺癌与肺内转移鉴别方法研究进展  

Research Progress in Distinguishing Methods of Simultaneous Multiple Primary Lung Cancer and Intrapulmonary Metastasis

作　　者：王继凡 张特[1] 丁翰林 董高超 许林[1] 蒋峰[1] Jifan WANG;Te ZHANG;Hanlin DING;Gaochao DONG;Lin XU;Feng JIANG(Department of Thoracic Surgery,the Affiliated Cancer Hospital of Nanjing Medical University,Jiangsu Cancer Hospital,Jiangsu Institute of Cancer Research,Jiangsu Key Laboratory of Molecular and Translation Cancer Research,Nanjing 210009,China)

机构地区：[1]南京医科大学附属肿瘤医院,江苏省肿瘤医院胸外科,江苏省肿瘤防治研究所,江苏省恶性肿瘤分子生物学及转化医学重点实验室,南京210009

出　　处：《中国肺癌杂志》2021年第5期365-371,共7页Chinese Journal of Lung Cancer

摘　　要：多原发性肺癌(multiple primary lung cancer, MPLC)是指在同一患者肺内不同部位同时或先后发生两个或两个以上原发病灶的肺癌,以诊断时间间隔6个月为界,MPLC分为同时性MPLC(synchronous MPLC, sMPLC)和异时性MPLC(metachronous MPLC, mMPLC)。sMPLC与肺内转移(intrapulmonary metastasis, IM)在治疗策略及预后上有着极大的差异。然而,目前临床上对于二者的区分鉴别存在许多争议。本文总结了目前诊断MPLC的主要方法,并重点介绍了区分MPLC和IM的最新研究进展,旨在为多灶性肺癌患者精准的诊断和治疗提供理论依据。Multiple primary lung cancer(MPLC) refers to lung cancer in which two or more primary lesions occurred simultaneously or successively in different parts of the same patient’s lungs. The diagnosis interval is 6 months. MPLC is divided into synchronous MPLC(sMPLC) and metachronous MPLC(mMPLC). sMPLC and intrapulmonary metastasis(IM) are different in treatment strategies and prognosis. However, there are many controversies about the distinction between the two in clinical practice. This article summarizes the current main methods of diagnosing MPLC, and focuses on the latest research progress in distinguishing MPLC from IM. It aims to provide a theoretical basis for accurate diagnosis and treatment of patients with multifocal lung cancer.

关 键 词：多原发性肺癌 肺内转移 肺肿瘤 精准诊断 

分 类 号：R734.2[医药卫生—肿瘤]