高危型人乳头瘤病毒持续感染患者阴道菌群与子宫颈局部免疫功能改变的关系研究  

Relation Studies of Vaginal Microbiota and Cervical Local Immunity in Persistent High-risk Human Papillomavirus Infection Patients

作　　者：邱雁 潘敏[1] QIU Yan;PAN Min(Maoming People’s Hospital,Maoming 525000,China)

机构地区：[1]广东省茂名市人民医院,广东茂名525000

出　　处：《中国医学创新》2021年第14期134-137,共4页Medical Innovation of China

基　　金：茂名市科技计划项目(2019369)。

摘　　要：目的:研究高危型人乳头瘤病毒(HR-HPV)持续感染患者阴道菌群与子宫颈局部免疫功能改变的关系。方法:选择2020年1月-2021年1月来本院进行HPV检查的145例女性为研究对象,其中HR-HPV阳性患者90例为研究组,55例HR-HPV阴性者为对照组。观察研究组患者感染情况,以及阴道微生态失调、菌群阳性率、T淋巴细胞亚群分布。结果:HPV感染的患者中以单一型感染为主,主要为HPV16(38.89%),复合型感染占比较少。研究组阴道微生态失调51.11%高于对照组的21.82%,乳酸杆菌异常、细菌性阴道炎、衣原体、滴虫、解脲脲原体阳性率均高于对照组,差异均有统计学意义(P<0.05)。研究组CD8^(+)高于对照组,CD3^(+)、CD4^(+)均低于对照组,差异均有统计学意义(P<0.05)。结论:HR-HPV感染患者,更容易出现阴道微生态失调,阴道菌群会发生变化,子宫颈免疫功能也会下降。Objective:To study the relationship between the vaginal microflora and the changes of local cervical immune function in patients with persistent high-risk human papillomavirus (HR-HPV) infection.Method:A total of 145 women who came to our hospital for HPV examination from January 2020 to January 2021 were selected as the study subjects,among which 90 patients with HR-HPV positive were included in the study group and 55 patients with HR-HPV negative were included in the control group.Infection,vaginal microdysregulation,positive rate of bacteria and distribution of T lymphocyte subsets were observed in the study group.Result:The majority of HPV infected patients were single type infection,mainly HPV16 (38.89%),complex type infection accounted for less.The positive rates of Lactobacillus abnormality,bacterial vaginitis,Chlamydia,Trichomonas and Ureaplasma ureticum in the study group were all higher than those in the control group,the differences were statistically significant (P<0.05).CD8^(+) in the study group was higher than that in the control group,while CD3^(+) and CD4^(+) were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion:Patients with HR-HPV infection are more likely to have vaginal microdysbiosis,changes in the vaginal microflora,and decreased cervical immune function.

关 键 词：高危型 人乳头瘤病毒 感染 阴道菌群 免疫功能 

分 类 号：R737.33[医药卫生—肿瘤]