利培酮联合盐酸舍曲林治疗强迫症患者的临床效果  

Clinical effect of risperidone combined with sertraline hydrochloride in the treatment of patients with obsessive compulsive disorder

作　　者：王小媛 刘柠[2] WANG Xiaoyuan;LIU Ning(No.4 Ward of Psychiatry Department,the Second Hospital of Rongfu Army in Shaanxi Province,Weinan 714200;Emergency Department,Xi'an Mental Health Center,Xi'an 710010,China)

机构地区：[1]陕西省荣复军人第二医院精神科四病区,陕西渭南714200 [2]西安市精神卫生中心急诊科,陕西西安710010

出　　处：《临床医学研究与实践》2021年第17期84-86,共3页Clinical Research and Practice

摘　　要：目的探讨利培酮联合盐酸舍曲林治疗强迫症患者的临床效果。方法将2016年5月至2019年5月我院收治的120例强迫症患者随机分为对照组(n=60)和试验组(n=60)。对照组采用盐酸舍曲林治疗,试验组采用利培酮联合盐酸舍曲林治疗。比较两组患者的耶鲁布朗强迫量表(Y-BOCS)评分、认知功能、临床疗效及不良反应发生情况。结果治疗后,两组的Y-BOCS评分均降低,且试验组低于对照组(P<0.05)。治疗后,两组的即刻记忆、延迟记忆评分均升高,连线测试A、B所需时间均缩短,总应答数增多,持续性错误数、非持续性错误数均减少,且试验组显著优于对照组(P<0.05)。试验组的治疗总有效率高于对照组(P<0.05)。两组患者的不良反应总发生率比较,差异不具有统计学意义(P>0.05)。结论利培酮联合盐酸舍曲林治疗强迫症患者的临床效果显著,可有效改善患者的认知功能,值得临床推广应用。Objective To explore the clinical effect of risperidone combined with sertraline hydrochloride in the treatment of patients with obsessive compulsive disorder.Methods A total of 120 patients with obsessive compulsive disorder admitted in our hospital from May 2016 to May 2019 were randomly divided into control group(n=60)and experimental group(n=60).The control group was treated with sertraline hydrochloride,and the experimental group was treated with risperidone combined with sertraline hydrochloride.The Yale-Brown obsessive compulsive scale(Y-BOCS)score,cognitive function,clinical efficacy and adverse reactions of the two groups were compared.Results After treatment,the Y-BOCS score in the two groups decreased,and that in the experimental group was lower than the control group(P<0.05).After treatment,the scores of immediate memory and delayed memory in the two groups increased,the time required for connecting test A and B shortened,the total number of answers increased,and the number of persistent errors and non persistent errors decreased,and those in the experimental group were significantly better than the control group(P<0.05).The total effective rate of treatment in the experimental group was higher than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Risperidone combined with sertraline hydrochloride in the treatment of patients with obsessive compulsive disorder has a significant clinical effect,it can effectively improve the cognitive function of patients,which is worthy of clinical promotion and application.

关 键 词：强迫症 舍曲林 利培酮 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]