GLUD1在肝细胞癌患者中表达特点的研究  

Research on Expression Characteristics of GLUD1 in Patients with Hepatocellular Carcinoma

作　　者：宋树娟 范琳[1] 王振国[2] SONG Shujuan;FAN Lin;WANG Zhenguo(Qingdao Third People’s Hospital,Qingdao 266000,China;不详)

机构地区：[1]山东省青岛市第三人民医院,山东青岛266000 [2]武警后勤学院附属医院救援研究所

出　　处：《中国医学创新》2021年第15期140-143,共4页Medical Innovation of China

基　　金：天津市科技计划项目(16ZXHLSY00120)。

摘　　要：目的:探讨谷氨酸脱氢酶1(glutamate dehydrogenase 1,GLUD1)在肝细胞癌患者中的表达特点。方法:在TCGA数据库中下载343例肝细胞癌患者临床数据及RNA表达数据,比较不同年龄、不同种族及不同肿瘤分期患者的GLUD1表达水平;按照GLUD1表达水平将患者排序,并分为高表达组(n=171)和低表达组(n=172),比较两组患者生存时间。结果:GLUD1表达水平与年龄无相关性(r=-0.102,P>0.05)。不同种族间GLUD1表达水平比较,差异无统计学意义(P>0.05)。Ⅰ、Ⅱ、Ⅲ、Ⅳ期患者GLUD1表达水平分别为(13.51±0.38)、(13.29±0.54)、(13.16±0.79)、(13.65±0.51),四组比较差异有统计学意义(F=3.915,P=0.007);Ⅱ、Ⅲ期患者的GLUD1表达水平均低于Ⅰ期,差异均有统计学意义(P<0.05)。GLUD1高表达组患者的中位生存时间长于GLUD1低表达组,差异有统计学意义(P<0.05)。结论:GLUD1高表达患者的肿瘤级别较低、生存期较长。Objective:To investigate the expression characteristics of GLUD1 in patients with hepatocellular carcinoma(HCC).Method:The clinical data and RNA expression data of 343 patients with hepatocellular carcinoma were downloaded from TCGA database,and the GLUD1 expression levels of patients with different ages,races and tumor stages were compared,and the patients were sorted according to the expression level of GLUD1,and divided into high expression group(n=171)and low expression group(n=172),and the survival time of two groups was compared.Result:There was no correlation between GLUD1 expression and age(r=-0.102,P>0.05).There was no significant difference in the expression level of GLUD1 among different races(P>0.05).The expression levels of GLUD1 inⅠ,Ⅱ,ⅢandⅣstage patients were(13.51±0.38),(13.29±0.54),(13.16±0.79)and(13.65±0.51),respectively,and the differences among four groups was statistically significant(F=3.915,P=0.007);the expression levels of GLUD1 in bothⅡandⅢstage patients were lower than that inⅠstage patients,the differences were statistically significant(P<0.05).The median survival time of patients in the group with high GLUD1 expression was longer than that in the group with low GLUD1 expression,and the difference was statistically significant(P<0.05).Conclusion:Patients with high expression of GLUD1 have lower tumor grade and longer survival time.

关 键 词：肝细胞癌 谷氨酸脱氢酶1 富集分析 

分 类 号：R735.7[医药卫生—肿瘤]