结肠息肉患者肠道菌群及临床特点分析  

Analysis of Intestinal Flora and Clinical Characteristics of Patients with Colonic Polyps

作　　者：陈文静 黄华丽 唐少波[1] 罗期 谢榕[1] 卢杰夫[1] CHEN Wenjing;HUANG Huali;TANG Shaobo;LUO Qi;XIE Rong;LU Jiefu(The First People’s Hospital of Nanning,Nanning 530022,China;不详)

机构地区：[1]南宁市第一人民医院,广西南宁530022

出　　处：《中国医学创新》2021年第15期148-151,共4页Medical Innovation of China

基　　金：广西壮族自治区卫生厅自筹经费科研课题项目(Z20180672)。

摘　　要：目的:分析结肠息肉患者肠道菌群及临床特点,提高对结肠息肉的诊断能力,预防肠癌。方法:选取2018年6月-2020年6月在本院就诊的60例经肠镜确诊为结肠息肉的患者为试验组,同期的60例健康体检者为对照组。收集晨起新鲜粪便,30 min内送检验科进行革兰染色涂片镜检了解肠道细菌情况。同时分析患者一般临床资料、Hp感染情况及相关实验室指标的特点。结果:试验组BMI≥24 kg/m2比例和便秘及结肠黑变病的发生率均高于对照组,差异均有统计学意义(P<0.05),两组Hp感染率比较,差异无统计学意义(P>0.05)。试验组G+杆菌减少的发生率高于对照组,G-杆菌和G+球菌增多的发生率均高于对照组,差异均有统计学意义(P<0.05);两组G+杆菌增多、G-杆菌减少、G+球菌减少、G-球菌增多、G-球菌减少的发生率比较,差异均无统计学意义(P>0.05)。两组肠道菌群细菌总数比较,差异无统计学意义(P>0.05)。试验组甘油三酯水平高于对照组,差异有统计学意义(P<0.05);两组空腹血糖、CRP、血清总胆汁酸水平比较,差异均无统计学意义(P>0.05)。结论:体重超重、长期便秘、血脂增高的人群可能更容易罹患结肠息肉,结肠息肉的发生发展可能与肠道菌群失调有关。Objective:To analyze the intestinal flora and clinical characteristics of patients with colonic polyps,improving the diagnostic ability of colonic polyps and prevent colorectal cancer.Method:A total of 60 patients with colonic polyps diagnosed by colonoscopy in our hospital from June 2018 to June 2020 were selected as the experimental group,and 60 healthy subjects in the same period were selected as the control group.Fresh feces were collected from the morning and sent to the laboratory for Gram staining smear microscopy within 30 minutes to understand the intestinal bacteria.The characteristics of general clinical data,HP infection and related laboratory indicators were analyzed.Result:The proportion of BMI≥24 kg/m2 and the incidence of constipation and colonic melanosis in the experimental group were higher than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in Hp infection rate between two groups(P>0.05).The incidence of decreased G+bacilli in the experimental group was higher than that in the control group,and the incidence of increased G-bacilli and G+cocci in the experimental group were higher than those in the control group,the differences were statistically significant(P<0.05).There were no statistical significance in the incidence of increased G+bacilli,decreased G-bacilli,decreased G+cocci,increased G-cocci and decreased G-cocci between two groups(P>0.05).There was no significant difference in the total number of intestinal flora between two groups(P>0.05).The triglyceride level in the experimental group was higher than that in the control group,the difference was statistically significant(P<0.05).There were no significant differences in the levels of fasting blood glucose,CRP and serum total bile acid between two groups(P>0.05).Conclusion:People with overweight,long-term constipation,hyperlipidemia are more likely to suffer from colon polyps,and the occurrence and development of colon polyps may be related to the imbalance of inte

关 键 词：结肠息肉 肠道菌群 临床特点 

分 类 号：R735.34[医药卫生—肿瘤]