血管内皮生长因子和促血管生成素2对甲状腺乳头状癌及颈部淋巴结转移的诊断价值  

Research on the predictive value of VEGF and Ang⁃2 in thyroid papillary carcinoma and its concomitant cervical lymph node metastasis

作　　者：刘美莲 苏法铭 李晓玲 彭晓霞 陈晓铭 LIU Meilian;SU Faming;LI Xiaoling;PENG Xiaoxia;CHEN Xiaoming(Department of Oncology Center,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524023,China;不详)

机构地区：[1]广东医科大学附属医院肿瘤中心,广东湛江524023 [2]广东医科大学附属医院内分泌科,广东湛江524023 [3]广东医科大学附属医院病理科,广东湛江524023

出　　处：《实用医学杂志》2021年第11期1441-1444,共4页The Journal of Practical Medicine

基　　金：湛江市科技攻关计划项目(编号:2020B01045)。

摘　　要：目的探讨甲状腺乳头状癌(PTC)组织标本中血管内皮生长因子(VEGF)和促血管生成素2(Ang⁃2)对PTC诊断及其并发颈部淋巴结转移的临床价值。方法选取经病理确诊的PTC患者86例(未合并颈部淋巴结转移的PTC患者病例41例和已并发颈部淋巴结转移的PTC患者病例45例)。采用免疫组织化学染色法Max Vision TM法检测PCT组织及癌旁正常甲状腺组织的VEGF和Ang⁃2的表达水平并记录上述相关临床资料。结果(1)VEGF的表达水平在PTC组织中明显高于癌旁组织(P<0.05);在未并发颈部淋巴结转移和已并发颈部淋巴结转移的PTC组织中的表达水平差异无统计学意义(P>0.05);(2)Ang⁃2在PTC组织中的表达明显高于癌旁组织(P<0.05);在未并发颈部淋巴结转移和已并发颈部淋巴结转移的PTC组织中的表达水平差异无统计学意义(P>0.05)。结论VEGF和Ang⁃2对于辅助PTC的诊断有一定的临床意义,VEGF和Ang⁃2对预测PTC是否伴有颈部淋巴结转移可能无诊断价值。Objective To investigate the clinical value of vascular endothelial growth factor(VEGF)and angiopoietins 2(Ang⁃2)in diagnosis of papillary thyroid carcinoma(PTC)and its concomitant cervical lymph node metastasis.Methods A total of 86 PTC patients confirmed by pathology(41 PTC patients without cervical lymph node metastasis and 45 PTC patients with cervical lymph node metastasis)were selected.The expression levels of VEGF and Ang⁃2 in PCT tissues and adjacent normal thyroid tissues were detected by MaxVisionTM method of immunohistochemical staining,and the above related clinical data were recorded.Results(1)The expression level of VEGF in PTC tissues was significantly higher than that in adjacent tissues(P<0.05).There was no differ⁃ence in the expression level between PTC without cervical lymph node metastasis and PTC with cervical lymph node metastasis(P>0.05).(2)The expression of Ang⁃2 in PTC tissues was significantly higher than that in para⁃carcinoma tissues(P<0.05).There was no difference in expression levels between PTC tissues without cervical lymph node metastasis and those with cervical lymph node metastasis(P>0.05).Conclusion VEGF and Ang⁃2 have certain clinical significance in assisting diagnosis of PTC.VEGF and ANG⁃2 may have no diagnostic value in predicting whether PTC associating with cervical lymph node metastasis.

关 键 词：甲状腺乳头状癌 血管内皮生长因子 促血管生成素2 淋巴结转移 

分 类 号：R736.1[医药卫生—肿瘤]