几种水生模式生物在持久性有机污染物毒理学评价中的研究进展  

Research progress of several aquatic biological models in toxicological evaluation of persistent organic pollutants

作　　者：王梦圆 张龙飞 汤云瑜 蔡友琼[1] 顾润润[1] 黄冬梅[1] 史永富[1] Mengyuan WANG;Longfei ZHANG;Yunyu TANG;Youqiong CAI;Runrun GU;Dongmei HUANG;Yongfu SHI(Fishery Products Quality Inspection and Test Centre(Shanghai),Key Laboratory of East China Sea Fishery Resources Exploitation,Ministry of Agriculture and Rural Affairs of China,East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai,200090,China;College of Food Science and Technology,Shanghai Ocean University,Shanghai,201306,China)

机构地区：[1]中国水产科学研究院东海水产研究所农业农村部水产品质量监督检验测试中心(上海),农业农村部东海渔业资源开发利用重点实验室,上海200090 [2]上海海洋大学食品学院,上海201306

出　　处：《环境化学》2021年第5期1361-1378,共18页Environmental Chemistry

基　　金：农业部公益性行业(农业)科研专项(201503108);国家自然科学基金(31501572)资助.

摘　　要：持久性有机污染物对环境及生物体产生的危害已引起全球范围内的持续关注。此类物质能够富集在生物体内,并通过食物链传递产生生物放大效应,进而引发“三致”作用、发育毒性、内分泌干扰效应等。水生模式生物具有饲养成本低、生理周期较短、繁殖量大等优点而被广泛应用于POPs毒理学评价。本文聚焦斑马鱼、青鳉鱼、非洲爪蟾等几种水生模式生物,对其在POPs毒性效应研究中的应用进展进行综述,包括POPs所致骨骼发育畸形、心血管系统病变、性腺发育异常等发育毒性,卵黄蛋白原的诱导、性腺指数、甲状腺激素水平的改变等内分泌干扰效应以及神经行为异常等相关研究内容,希望为POPs污染现状评估以及毒理效应的深入探索、疾病预测模型的建立提供资料参考,并对该领域研究过程中生物模型的筛选具有借鉴意义。The harm of persistent organic pollutants(POPs)to the environment and organisms has attracted continuous attention all over the world.Such substances can be enriched in organisms and produce biological amplification effect through food chain transmission,which in turn triggers“three toxicity”effects,developmental toxicity,endocrine disrupting effects,etc.Aquatic model organisms have been widely used in toxicological evaluation of POPs because of their low feeding cost,short physiological cycle and large reproduction.In this paper,several aquatic biological models,such as zebrafish(Danio rerio),medaka(Oryzias latipes)and Xenopus laevis,are focused on to review the application of these models in the study of toxic effects caused by POPs.These toxic effects include developmental toxicity such as skeletal malformation,cardiovascular diseases,gonadal dysplasia,reproductive endocrine disrupting effects such as vitellogenin induction,gonadal index and thyroid hormone levels,as well as neurobehavioral abnormalities and other related research contents.We hope to provide reference for the assessment of POPs pollution status,the in-depth exploration of the toxicological effects of POPs,and establishment of disease prediction model.At the same time,it provides reference for the screening of biological models in the research process of this field.

关 键 词：水生模式生物 持久性有机污染物 斑马鱼 青鳉鱼 非洲爪蟾 毒理效应 

分 类 号：X171.5[环境科学与工程—环境科学]