LncRNA H19基因多态性与乳腺癌遗传易感性关联的Meta分析  

Meta analysis of the association between LncRNA H19 gene polymorphism and breast cancer genetic susceptibility

作　　者：李晓波[1] 李婷[2] 白素琴[1] 张清雯 LI Xiaobo;LI Ting;BAI Suqin;ZHANG Qingwen(Molecular Diagnostic Laboratory,Department of Microbiology and Immunology,3201 Hospital Affiliated to Medical College of Xi′an Jiaotong University,Hanzhong,Shaanxi 723000,China;Department of Clinical Laboratory,3201 Hospital Affiliated to Medical College of Xi′an Jiaotong University,Hanzhong,Shaanxi 723000,China)

机构地区：[1]西安交通大学医学院附属3201医院微生物免疫检验科分子诊断实验室,陕西汉中723000 [2]西安交通大学医学院附属3201医院临床医学检验科,陕西汉中723000

出　　处：《国际检验医学杂志》2021年第12期1507-1512,共6页International Journal of Laboratory Medicine

摘　　要：目的系统评价长链非编码RNA(LncRNA)H19基因rs217727和rs2839698单核苷酸多态性(SNP)位点与乳腺癌遗传易感性的关系。方法检索PubMed、Embase、Elsevier、中国知网(CNKI)、万方数据库、维普(VIP)数据库,收集关于LncRNA H19基因多态性与乳腺癌遗传易感性相关的病例对照研究。采用STATA12.0软件Meta-analysis模块进行LncRNA H19基因多态性与乳腺癌遗传易感性关联的Meta分析。结果关于rs217727 SNP位点的5篇文献共纳入乳腺癌患者3178例,健康对照者3392例;关于rs2839698 SNP位点的3篇文献共纳入乳腺癌患者2607例,健康对照者2827例。Meta分析结果显示,rs217727与rs2839698 SNP位点4种遗传学模式[等位基因(T vs.C)、加性模式(TT vs.CC)、隐性模式(TT vs.CT+CC)、显性模式(TT+CT vs.CC)]在病例组与对照组间比较,差异均无统计学意义(P>0.05)。人群分层研究显示,中国汉族人群和伊朗人群rs217727 SNP位点4种遗传学模式在病例组与对照组间比较,差异均无统计学意义(P>0.05)。中国汉族人群rs2839698 SNP位点4种遗传学模式在病例组与对照组间比较,差异均无统计学意义(P>0.05)。伊朗人群rs2839698 SNP位点4种遗传学模式在病例组与对照组间比较,差异有统计学意义(P<0.05)。结论中国汉族人群LncRNA H19基因rs217727和rs2839698 SNP位点4种遗传学模式与乳腺癌遗传易感性无关。Objective To systematically evaluate the relationship between the rs217727 and rs2839698 single nucleotide polymorphism(SNP)sites of long non-coding RNA(LncRNA)H19 gene and the genetic susceptibility of breast cancer.Methods PubMed,Embase,Elsevier,CNKI,Wanfang database and VIP database were searched to collect case-control studies on the relationship between LncRNA H19 gene polymorphism and genetic susceptibility of breast cancer.Meta-analysis module of STATA12.0 software was used to analyze the association between LncRNA H19 gene polymorphism and genetic susceptibility of breast cancer.Results Five articles on rs217727 SNP site included 3178 breast cancer patients and 3392 healthy controls.Three articles on rs2839698 SNP site included 2607 breast cancer patients and 2827 healthy controls.The results of Meta-analysis showed that there was no significant difference between the case group and the control group of 4 genetic patterns of rs217727 and rs2839698 SNP sites[allele(T vs.C),additive(TT vs.CC),recessive(TT vs.CT+CC)and dominant(TT+CT vs.CC)](P>0.05).The population stratification study showed that the 4 genetic patterns of rs217727 SNP site between the Chinese Han population and the Iranian population was not statistically different between the case group and the control group(P>0.05).The 4 genetic patterns of rs2839698 SNP site in the Chinese Han population was not statistically different between the case group and the control group(P>0.05).The 4 genetic patterns at rs2839698 SNP site in Iranian population was compared between the case group and the control group,and the difference was statistically significant(P<0.05).Conclusion The 4 genetic patterns of LncRNA H19 gene rs217727 and rs2839698 SNP sites in Chinese Han population are not related to the genetic susceptibility of breast cancer.

关 键 词：乳腺癌 长链非编码RNA H19基因 单核苷酸多态性 META分析 

分 类 号：R737.9[医药卫生—肿瘤]