基于益气聪明汤的抗氧化功能加减方配伍研究  

Study on compatibility of modified Yiqi Congming Decoction based on its anti-oxidative effect

作　　者：张明霞[1] 韦敏[1] 周义峰[1,2] 郭严冬 ZHANG Ming-xia;WEI Min;ZHOU Yi-feng;GUO Yan-dong(Jiangsu Key Laboratory for the Research and Utilization of Plant Resources,Institute of Botany,Jiangsu Province and Chinese Academy of Sciences,Nanjing 210014,China;Dongtai Institute of Tidal Flat,Nanjing Branch of Chinese Academy of Sciences,Dongtai 224237,China)

机构地区：[1]江苏省中国科学院植物研究所,江苏省植物资源研究与利用重点实验室,南京210014 [2]中国科学院南京分院东台滩涂研究院,东台224237 [3]江苏省中国科学院植物研究所标本馆,江苏省植物资源研究与利用重点实验室,南京210014

出　　处：《中华中医药杂志》2021年第5期2988-2990,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：海洋公益性行业科研专项(No.201505023)。

摘　　要：目的:筛选出抗氧化功能最佳的益气聪明汤配伍。方法:采用正交设计法对益气聪明汤进行加减方配伍,对给药后D-半乳糖氧化损伤小鼠肝脏中MDA含量、SOD活性和GSH-Px活性进行测定,研究益气聪明汤加减法的抗氧化功能。结果:丹参、葛根、短梗五加、北沙参、人参、黄芪、甘草和白芍的益气聪明汤配伍能明显增加D-半乳糖氧化损伤小鼠肝脏中SOD和GSH-Px活性,降低肝脏中MDA含量。结论:抗氧化作用最佳的益气聪明汤配伍为丹参10g、葛根10g、短梗五加10g、北沙参10g、人参16g、黄芪16g、甘草16g和白芍3g。Objective:Compatibility of Yiqi Congming Decoction with the best anti-oxidative effect was screened.Methods:Compatibility of Yiqi Congming Decoction is modified by using orthogonal design method.MDA content,SOD activity,and GSH-Px activity in liver of oxidative damage mouse by D-galactose after administration are determined,and the antioxidant function of Yiqi Congming Decoction is studied.Results:Compatibility of Yiqi Congming Decoction including Salvia Miltrorrhiza,Radix Puerariae,Acanthopanax Sessiliflorus,Radix Glehniae,Ginseng,Milkvetch Root,Radix Glycyrrhizae and White Paeony Root could increase SOD and GSH-Px activities in the liver of oxidative damage mice by D-galactose,and decrease MDA content in its liver.Conclusion:The anti-oxidative effect of compatibility of Yiqi Congming Decoction including Salvia Miltrorrhiza 10 g,Radix Puerariae 10 g,Acanthopanax Sessiliflorus 10 g,Radix Glehniae 10 g,Ginseng 16 g,Milkvetch Root 16 g,Radix Glycyrrhizae 16 g and White Paeony Root 3 g was best.

关 键 词：益气聪明汤 配伍 D-半乳糖 氧化损伤 抗氧化活性 

分 类 号：R289.1[医药卫生—方剂学]