新型咔唑桥联双咪唑盐的合成、表征及抑菌活性  

Synthesis、Characterization and Antibacterial Activity of A Novel Bis-imidazole Salt Based on Carbazole

作　　者：罗杰伟[1] 赵波[1] 张仕禄[1] 刘军 LUO Jie-wei;ZHAO Bo;ZHANG Shi-lu;LIU Jun(Basic Medical School, North Sichuan Medical College, Nanchong 637000,China)

机构地区：[1]川北医学院基础医学院,四川南充637000

出　　处：《合成化学》2021年第5期435-439,共5页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(81801768);教育部产学合作协同育人项目(201801201004,201801332045,201801272041);四川省科学技术厅项目(2017063);南充市科学技术局项目(18SXHZ0133)。

摘　　要：以咔唑作为桥联基团,合成了两个新型N-杂环卡宾前体:3,6-二(3′-(N-苯基-2-乙酰胺基)咪唑)-9-乙基咔唑二氯化物(L)和3,6-二(3′-乙基咪唑)六氟磷酸盐(M),其结构经^(1)H NMR,^(13)C NMR和XRD表征。初步的抑菌实验结果表明,化合物L和M对金黄色葡萄球菌及大肠杆菌具有一定的抑菌作用。The two novel N-heterocyclic carbene precursors 3,6-bis(3′-(N-phenyl-2-acetamido)imidazole)-9-ethylcarbazole dichloride(L)and3,6-bis(3′-ethylimidazole)hexafluoropho sphate(M)were synthesized by using carbazole as bridging group,The structures were characterized by ^(1)H NMR,^(13)C NMR and X-ray.Preliminary bacteriostatic experiments showed that compounds L and M had certain bacteriostatic effect on staphylococcus aureus and escherichia coli.

关 键 词：N-杂卡宾 咪唑 抑菌性 晶体结构 合成 

分 类 号：O62[理学—有机化学]