清肠通便胶囊联合双歧杆菌乳杆菌三联活菌片治疗小儿功能性便秘的疗效及对肠神经递质水平的影响  

Curative effect of Qingchang Tongbian capsule and live combined bifidobacterium and lactobacillus tablets in treatment of children with functional constipation and impact on levels of intestinal neurotransmitters

作　　者：盛凯华[1] 宋健辉[1] 黄祖辉[1] SHENG Kai-Hua;SONG Jian-Hui;HUANG Zu-Hui(Qidong People's Hospital,Qidong,Jiangsu 226200,China)

机构地区：[1]启东市人民医院,江苏启东226200

出　　处：《中国妇幼保健》2021年第11期2537-2541,共5页Maternal and Child Health Care of China

基　　金：江苏省临床医学科技专项项目(BL2017167)。

摘　　要：目的探讨清肠通便胶囊联合双歧杆菌乳杆菌三联活菌片治疗小儿功能性便秘(FC)的疗效及对其肠神经递质[P物质(SP)、生长抑素(SS)及一氧化氮(NO)]水平的影响,为临床治疗提供参考依据。方法选取94例FC患儿作为研究对象,随机分为对照组和观察组各47例,两组均给予基础治疗,对照组在此治疗基础上给予双歧杆菌乳杆菌三联活菌片治疗,观察组在对照组治疗基础上加用清肠通便胶囊,观察两组临床疗效,检测血清SP、SS、NO水平,并观察两组患者症状改善情况及肠道菌群变化情况,统计不良反应发生率及复发情况。结果观察组临床疗效明显高于对照组,差异有统计学意义(P<0.05);治疗后两组便秘症状评分明显下降,粪便性状分级明显升高,与治疗前比较差异有统计学意义(均P<0.05),且观察组改善情况明显优于对照组,差异有统计学意义(均P<0.05);治疗后两组SP水平明显升高,SS及NO水平均明显降低,与治疗前比较差异有统计学意义(均P<0.05),且观察组SP水平明显高于对照组,SS、NO水平明显低于对照组,差异有统计学意义(均P<0.05);治疗后两组肠道菌群(肠杆菌、葡萄球菌、乳杆菌、双歧杆菌、酵母菌)优于治疗前,且观察组优于对照组,差异有统计学意义(均P<0.05);治疗期间两组不良反应发生率比较,差异无统计学意义(P>0.05);随访1个月后观察组复发率明显低于对照组,差异有统计学意义(P<0.05)。结论清肠通便胶囊与双歧杆菌乳杆菌三联活菌片联合治疗小儿FC疗效显著,能够明显提高血清SP水平,同时降低SS及NO水平,改善患儿临床症状及肠道菌群失调情况,具有很高的临床应用价值。Objective To explore the curative effect of Qingchang Tongbian capsule and live combined bifidobacterium and lactobacillus tablets in treatment of children with functional constipation and impact on levels of intestinal neurotransmitters [P substance( SP),somatostatin( SS),and nitric oxide( NO) ],provide a reference basis for clinical treatment. Methods Ninety-four children with functional constipation were selected and randomly divided into control group and observation group,47 cases in each group. The children in the two groups were given basic treatment. On this basis,the children in control group were treated with live combined bifidobacterium and lactobacillus tablets,the children in observation group were treated with Qingchang Tongbian capsule and live combined bifidobacterium and lactobacillus tablets. The clinical effects in the two groups were observed,the levels of serum SP,SS,and NO were detected. The improvements of symptoms and changes of intestinal flora in the two groups were observed,the incidence rates of adverse reactions and recurrence rates were calculated. Results The clinical effect in observation group was statistically significantly better than that in control group( P<0. 05);after treatment,constipation symptom scores in the two groups decreased significantly,degrees of stool characteristics increased significantly,compared with before treatment,there were statistically significant differences( P<0. 05),the improvement in observation group was statistically significantly better than that in control group( P<0. 05);after treatment,SP levels in the two groups increased significantly,SS and NO levels decreased significantly,compared with before treatment,there were statistically significant differences( P<0. 05),SP level in observation group was statistically significantly higher than that in control group,SS and NO levels in observation group were statistically significantly lower than those in control group( P < 0. 05);after treatment,intestinal floras( Enterobacteriaceae,Staphylococcus,

关 键 词：功能性便秘 清肠通便胶囊 双歧杆菌乳杆菌三联活菌片 疗效 儿童 肠神经递质 

分 类 号：R574.5[医药卫生—消化系统] R574.62[医药卫生—内科学]