脑胶质母细胞瘤术中超声造影特征与异柠檬酸脱氢酶1表达的相关性  

Correlation between the characteristic of intraoperative contrast enhanced ultrasound and expression of isocitrate dehydrogenase 1 in glioblastoma

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作  者:邬冬芳[1] 何文[1] 林松[2] 韩波[2] 于腾飞[1] Wu Dongfang;He Wen;Lin Song;Han Bo;Yu Tengfei(Department of Ultrasound,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区:[1]首都医科大学附属北京天坛医院超声科,100070 [2]首都医科大学附属北京天坛医院神经外科,100070

出  处:《中华超声影像学杂志》2021年第5期397-401,共5页Chinese Journal of Ultrasonography

基  金:国家自然科学基金面上项目(81071239);中国医师协会科技新星计划(kjxx2019001)。

摘  要:目的探讨脑胶质母细胞瘤超声造影声像图特性与异柠檬酸脱氢酶1(isocitrate dehydrogenase-1,IDH1)基因表达之间的关系。方法回顾性分析2018年5月至2019年4月北京天坛医院30例神经外科胶质母细胞瘤患者术中肿瘤超声造影资料,观察其声像图特征(肿瘤是否累及胼胝体结构,超声造影增强后肿瘤边界清晰程度以及肿瘤超声造影强化后有无坏死区域)。测量肿瘤无强化区域面积与肿瘤强化区域边缘面积(即肿瘤坏死区域/整体肿瘤区域,tumor necrosis area/whole body area,N/W area)之间的比值,分析与IDH1基因表达水平(弱阳性、中等阳性、强阳性)的相关性。结果超声造影后IDH1阳性与阴性组间肿瘤边界清晰程度、超声造影后肿瘤坏死差异有统计学意义(均P<0.05)。IDH1表达水平与超声造影增强模式N/W area指标间呈负相关(r=-0.756,P<0.05),提示IDH1基因表达水平与肿瘤坏死区域呈负相关。结论超声造影可以准确区分胶质母细胞瘤活跃增殖区域及出血坏死区。通过超声造影准确识别肿瘤坏死区域范围有助于预测IDH1基因表达及基因表达水平。Objective To explore the correlation between the characteristics of contrast-enhanced sonography of intraoperative glioblastoma multiform(GBM)and molecular markers of isocitrate dehydrogenase-1(IDH1).Methods A retrospective analysis were performed in 30 patients who underwent neurosurgery and pathologically confirmed to be GBM at Beijing Tiantan Hospital from May 2018 to April 2019.All neurosurgical glioblastoma patients after craniotomy underwent conventional ultrasound and contrast-enhanced ultrasound(CEUS)guided navigation.The characteristics of the ultrasound imaging(whether the tumor involves the structure of the corpus callosum,the clarity of the tumor boundary after enhanced ultrasound and whether the tumor has necrotic areas with enhanced ultrasound images)were analyzed.The ratio between tumor necrosis area and whole tumor area(N/W)was measured,and the correlation with IDH1 gene expression was analyzed.Results There were statistical differences in clarity of tumor boundary after CEUS and tumor necrosis after CEUS between positive IDH1 and negative IDH1 groups(all P<0.05).The positive expression of IDH1 was negatively correlated with the N/W area of the contrast-enhanced ultrasound mode(r=-0.756,P<0.05),suggesting that the expression level of IDH1 gene was negatively correlated with the area of tumor necrosis.Conclusions Ultrasound contrast agent examination can more accurately distinguish the active proliferation area,hemorrhagic necrosis area and peripheral edema area of glioblastoma.Accurately identifying the extent of tumor necrosis area through ultrasound contrast agent examination can predict expression of IDH1.

关 键 词:超声造影 胶质母细胞瘤 异柠檬酸脱氢酶 

分 类 号:R739.41[医药卫生—肿瘤]

 

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