年龄与病程对功能性便秘患者血清脑肠肽的影响研究  

Research on the effect of age and course on serum brain-gut peptide in patients with functional constipation

作　　者：陈峰[1] 陈伟 郑玉金[1] 邓正明[1] CHEN Feng;CHEN Wei;ZHENG Yu-jin;DENG Zheng-ming(Department of Coloproctology,the First Hospital of Fuzhou,Fujiang,350009,China;不详)

机构地区：[1]福州市第一医院肛肠科,福建福州350009 [2]福州千里心理咨询有限公司

出　　处：《中国冶金工业医学杂志》2021年第3期255-256,共2页Chinese Medical Journal of Metallurgical industry

基　　金：福建省自然科学基金项目(2016J01601)。

摘　　要：目的观察不同年龄、病程的功能性便秘患者的血清脑肠肽情况。方法将符合罗马Ⅲ功能性便秘诊断标准的60例患者用酶联免疫吸附法(ELISA)检测外周血浆中胃泌素(GAS)、血管活性肠肽(VIP)、5-羟色胺(5-HT)、P物质(SP)等血清脑肠肽的浓度,并按年龄与病程进行分类分析。结果各病程段功能性便秘患者的血清脑肠肽指标比较差异有统计学意义(P<0.05);而各年龄段之间比较差异无统计学意义(P>0.05)。结论功能性便秘患者的病程是影响血清脑肠肽代谢的因素之一。Objective To observe serum brain-gut peptide in different ages and course of the patients with functional constipation.Methods60 patients meeting the diagnostic criteria of RomeⅢfunctional constipation were tested by enzyme-linked immunosorbent assay(ELISA)for concentrations of serum brain-gut peptides such as gastrin(GAS),vasoactive intestinal peptide(VIP),serotonin(5-HT),substance P(SP),etc.,who were classified and analyzed according to age and course of disease.Results There were statistically significant differences in serum brain-gut peptides of the patients with functional constipation in the different stages of disease(P<0.05);but there were no statistically significant differences in different age groups(P>0.05).Conclusion The course of functional constipation is one of the effective factors affecting the metabolism of serum brain-gut peptides.

关 键 词：功能性便秘 脑肠肽 胃泌素 血管活性肠肽 5-羟色胺 P物质 

分 类 号：R574.62[医药卫生—消化系统]