Central precocious puberty as a prelude of gonad dysplasia  

作　　者：Lele Li Chunxiu Gong 

机构地区：[1]Department of Endocrinology,Genetics,Metabolism and Adolescent Medicine,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing,China

出　　处：《Pediatric Investigation》2019年第1期50-54,共5页儿科学研究（英文）

摘　　要：There is increasing evidence that patients with gonad dysplasia,as characterized by absent or incomplete puberty,can also exhibit central precocious puberty(CPP).Herein,we review the reported cases that manifest with both gonad dysplasia and CPP.Further,we examine the hypothesis that these patients exhibit a normal hypothalamic-pituitarygonadal axis,hypogonadism,and the presence of residual gonadal function,and that the onset of disease is related to early initiation of the hypothalamic-pituitary-gonadal axis.Thus,we suggest that CPP is a prelude of some partial hypogonadism.

关 键 词：Gonad dysplasia Central precocious puberty Turner syndrome Klinefelter syndrome 

分 类 号：TP[自动化与计算机技术]