雷贝拉唑联合替普瑞酮对慢性胃炎患者胃动力指标与复发率的影响  

Effects of rabeprazole combined with tipredone on gastric motility and recurrence rate in patients with chronic gastritis

作　　者：王丽娟 WANG Lijuan(Department of Pharmacy,Fuxin Second People’s Hospital of Liaoning Province,Fuxin,Liaoning,123000,China)

机构地区：[1]辽宁省阜新市第二人民医院药剂科,辽宁阜新123000

出　　处：《当代医学》2021年第18期34-37,共4页Contemporary Medicine

摘　　要：目的探讨雷贝拉唑联合替普瑞酮治疗对慢性胃炎(chronic gastritis,CG)患者胃动力指标与复发率的影响。方法选取2018年1—12月本院收治的86例CG患者作为研究对象,随机分为对照组与研究组,每组43例。对照组采用替普瑞酮治疗,研究组在对照组基础上联合雷贝拉唑治疗。比较两组临床疗效、治疗前后症状积分、胃动力指标、改善时间及复发率。结果研究组治疗总有效率为100.00%,明显高于对照组的83.72%(P<0.05)。治疗前,两组餐后饱胀、食欲减退、上腹隐痛症状积分比较差异无统计学意义;治疗后,研究组餐后饱胀、食欲减退、上腹隐痛症状积分均低于对照组(P<0.05)。治疗前,两组胃泌素-17、胃动素比较差异无统计学意义;治疗后,研究组胃泌素-17、胃动素均明显低于对照组(P<0.05)。研究组餐后饱胀消失时间、胃镜检查显示愈合时间、食欲减退好转时间、幽门螺杆菌检验转阴时间均短于对照组(P<0.05)。研究组复发率为2.33%(1/43),低于对照组的18.60%(8/43),差异有统计学意义(P<0.05)。结论雷贝拉唑联合替普瑞酮治疗CG效果优于替普瑞酮单一用药治疗,可有效改善临床症状和胃动力,缩短治疗时间,降低复发率,值得临床推广应用。Objective To investigate the effects of rabeprazole combined with tipredone on gastric motility indexes and recurrence rate in patients with chronic gastritis(CG).Methods 86 CG patients admitted to our hospital from January to December 2018 were selected as the research subjects and they were randomly divided into control group and study group,with 43 cases in each group.The control group was treated with tipredone,and the study group was treated with rabeprazole on the basis of the control group.Clinical efficacy,symptom score,gastric motility index,improvement time and recurrence rate were compared between the two groups.Results The total effective rate of the study group was100.00%,which was significantly higher than 83.72%of the control group(P<0.05).Before treatment,there was no significant difference in symptom scores of postprandial fullness,loss of appetite and dark pain in upper abdomen between the two groups.After treatment,the scores of postprandibular fullness,anorexia and epigastric dull pain in the study group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference between the two groups in gastrin-17 and motilin.After treatment,gastrin-17 and motilin in the study group were significantly lower than those in the control group(P<0.05).The disappearance time of postprandibular fullness,the healing time of gastroscopy,the improvement time of anorexia,and the negative time of Helicobacter pylori test in the study group were shorter than those in the control group(P<0.05).The recurrence rate of the study group was 2.33%(1/43),which was lower than 18.60%of the control group(8/43),and the difference was statistically significant(P<0.05).Conclusion Rabeprazole combined with tipredone in CG treatment is better than tipredone single treatment,can better improve the clinical symptoms and gastric motility,shorten the treatment time,reduce the recurrence rate,it is worthy of clinical application.

关 键 词：雷贝拉唑 替普瑞酮 CG患者 胃动力指标 复发率 影响 

分 类 号：R573.3[医药卫生—消化系统]