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作 者:方柳庄 夏伦文 许巧 杨文标 FANG Liuzhuang;XIA Lunwen;XU Qiao(Department of Internal Medicine,Sanhe Hospital,Huiyang District,Guangdong Province,Huizhou 516211,China)
机构地区:[1]惠阳区三和医院消化内科,广东省惠州市516211
出 处:《临床合理用药杂志》2021年第14期9-11,共3页Chinese Journal of Clinical Rational Drug Use
摘 要:目的比较注射用艾司奥美拉唑钠与兰索拉唑治疗消化性溃疡所致急性上消化道出血的临床效果。方法选取2018年9月-2019年12月惠阳区三和医院收治的消化性溃疡所致急性上消化道出血患者116例,运用随机数字表法分为观察组和对照组,每组58例。2组在常规治疗基础上,对照组使用注射用兰索拉唑治疗,观察组采用注射用艾司奥美拉唑钠治疗。比较2组治疗效果,治疗前后胃液p H值及临床指标恢复时间。结果治疗5 d,观察组总有效率为96.55%,高于对照组的79.31%(χ^(2)=8.132,P=0.004);治疗5 d后,2组胃液p H值均较治疗前升高(P <0.01),且观察组胃液p H值高于对照组(P <0.01);观察组止血时间、血压稳定时间、腹痛缓解时间均短于对照组(P <0.01)。结论使用注射用艾司奥美拉唑钠治疗消化性溃疡所致急性上消化道出血患者,相比于注射用兰索拉唑,在疗效方面、胃液p H提高方面、临床指标恢复时间方面效果均更佳,值得推广应用。Objective To compare the clinical effects of esomeprazole sodium injection and lansoprazole injection in the treatment of acute upper gastrointestinal bleeding caused by peptic ulcer. Methods A total of 116 patients with acute upper gastrointestinal bleeding caused by peptic ulcer admitted to Sanhe Hospital in Huiyang District from September 2018 to December 2019 were divided into observation group and control group using a random number table method,with 58 cases in each group. The control group was treated with lansoprazole injection,and the observation group was treated with esomeprazole sodium injection. Compare the treatment effect of the two groups,the p H value of gastric juice before and after treatment,and the clinical index recovery time. Results After 5 days of treatment,the total effective rate in the observation group was96. 55%,which was higher than 79. 31% in the control group( χ^(2)= 8. 132,P = 0. 004). After 5 days of treatment,the p H value of gastric juice in the two groups was higher than before treatment( P < 0. 01),and the p H value of gastric juice in the observation group was higher than that of the control group( P < 0. 01). The hemostasis time,blood pressure stabilization time,and abdominal pain relief time in the observation group were shorter than those in the control group( P < 0. 01).Conclusion Esomeprazole sodium injection in the treatment of patients with acute upper gastrointestinal bleeding caused by peptic ulcer,compared with lansoprazole injection,has better effects in terms of curative effect,gastric juice p H increase,and clinical recovery indicators,it is worth promoting and applying.
关 键 词:消化性溃疡 急性上消化道出血 注射用艾司奥美拉唑钠 注射用兰索拉唑 临床效果
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