消臌软坚丸联合西药治疗肝硬化顽固性腹水的临床效果  

Clinical effect of Xiaogu Ruanjian pill combined with western medicine in the treatment of refractory ascites due to liver cirrhosis

作　　者：李朝晖 张晓龙 郭彦清 李学 王晓玲 沈丽贤 康艳艳 房冲冲 LI Zhaohui;ZHANG Xiaolong;GUO Yanqing(The Second Ward of Hebei Traditional Chinese Medicine Liver Disease Hospital,Hebei Province,Shijiazhuang 050800,China)

机构地区：[1]河北中医肝病医院二病区,石家庄市050800 [2]河北中医肝病医院超声科,石家庄市050800 [3]河北中医肝病医院一病区,石家庄市050800

出　　处：《临床合理用药杂志》2021年第14期12-14,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察消臌软坚丸联合西药治疗肝硬化顽固性腹水的临床效果。方法选取2015年1月-2016年1月河北中医肝病医院收治的肝硬化顽固性腹水患者88例,采用抽签法随机分为观察组和对照组,各44例。在常规治疗基础上,对照组患者予安络化纤丸治疗,观察组予消臌软坚丸治疗。比较2组患者治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、直接胆红素(DBil)、白蛋白(ALB)、球蛋白(GLB)]水平、腹水量、肝脏硬度变化情况,同时统计患者治疗后3年内复发情况和3年生存率。结果治疗后,2组ALT、AST、DBil、ALB、GLB水平及腹水量、肝脏硬度均较治疗前改善,且观察组改善程度好于对照组(P均<0.01);观察组治疗后3年各年度复发率均低于对照组(P <0.05);观察组3年生存率为97.73%,高于对照组的86.36%(χ^(2)=3.880,P=0.049)。结论消臌软坚丸联合西药治疗肝硬化顽固性腹水,可有效改善肝功能指标,降低腹水量,并降低复发率,提高生存率,值得临床推广应用。Objective To observe the clinical effect of Xiaogu Ruanjian pill combined with western medicine in the treatment of refractory ascites due to liver cirrhosis. Methods From January 2015 to January 2016,88 patients with refractory ascites due to liver cirrhosis were selected and randomly divided into observation group and control group with 44 cases in each group. On the basis of conventional treatment,the control group was treated with Anluo Huaxian pill,and the observation group was treated with Xiaogu Ruanjian pill. The levels of liver function indexes( ALT,AST,DBil,ALB,GLB),ascites volume and liver hardness were compared between the two groups before and after treatment. The recurrence rate and 3-year survival rate were also calculated. Results After treatment,ALT,AST,DBil,ALB,GLB levels,ascites volume and liver hardness of the two groups were improved,and the improvement degree of the observation group was better than that of the control group( P < 0. 01);The recurrence rate of the observation group was lower than that of the control group in three years( P < 0. 05);The 3-year survival rate of the observation group was 97. 73%,which was higher than 86. 36% of the control group( χ^(2)= 3. 880,P = 0. 049). Conclusion Xiaogu Ruanjian pill combined with western medicine in the treatment of refractory ascites of liver cirrhosis can effectively improve liver function index,reduce the amount of ascites,reduce the recurrence rate and improve the survival rate,which is worthy of clinical application.

关 键 词：肝硬化顽固性腹水 消臌软坚丸 安络化纤丸 临床效果 

分 类 号：R575.2[医药卫生—消化系统]