超声E成像在非酒精性脂肪性肝病诊断中的应用  

Application of ultrasound E imaging in the diagnosis of non-alcoholic fatty liver disease

作　　者：王鹏[1] 娄可新 王琛[2] 厉志洪 崔怀信[3] WANG Peng;LOU Ke-xin;WANG Chen;CUI Huai-xin(Department of Ultrasound,Xuzhou Central Hospital of Jiangsu Province,Xuzhou Jiangsu,221009,China;不详)

机构地区：[1]江苏省徐州市中心医院超声医学科,江苏徐州221009 [2]江苏省徐州市中心医院磁共振室 [3]江苏省徐州市中心医院乳腺外科

出　　处：《中西医结合肝病杂志》2021年第6期543-547,共5页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：江苏省徐州市科技资助项目(No.KC16SY161)。

摘　　要：目的:探讨超声E成像在非酒精性脂肪性肝病(NAFLD)中的诊断价值。方法:选择2018年1月至2019年12月180例非酒精性脂肪肝患者为观察组(NAFLD组),另选择同期80例健康体检者为健康对照组,两组患者均进行超声E成像检查杨氏模量值,绘制接收者操作特征曲线(ROC)评价杨氏模量值对NAFLD的诊断价值。对NAFLD患者肝组织病理标本进行分期,比较不同病理分期NAFLD患者杨氏模量值,ROC曲线评价杨氏模量值对NAFLD不同病理分期的鉴别诊断价值。结果:NAFLD组杨氏模量值显著高于健康对照组,且随着病理分期的加重,杨氏模量值呈逐渐升高的趋势(P<0.05)。绘制ROC曲线,结果发现杨氏模量值诊断NAFLD的曲线下面积为0.8524,诊断临界值为5.732 kPa,敏感度为81.05%,特异度为100%,约登指数为0.8105。杨氏模量值还对肝硬化、肝纤维化、肝炎不同病理NAFLD具有较高的鉴别诊断价值,曲线下面积分别为0.9016、0.9964、0.9875。结论:超声E成像检查NAFLD患者杨氏模量值升高,可用于临床NAFLD的诊断和不同病理分期的鉴别诊断。Objective:To investigate the value of ultrasound E imaging in the diagnosis of non-alcoholic fatty liver disease(NAFLD).Methods:A total of 120 patients with non-alcoholic fatty liver from January 2018 to December 2019 were selected as NAFLD group,and another 80 healthy subjects were selected as healthy control group.Ultrasound E imaging was performed on both groups.Modulus value,draw receiver operating characteristic curve(ROC)to evaluate the diagnostic value of Young's modulus value to NAFLD.Liver pathological specimens were staged,and the Young′s modulus values of NAFLD patients with different pathological stages were compared.The ROC curve evaluated the differential diagnosis value of Young′s modulus values for different pathological stages of NAFLD.Results:The Young′s modulus value of NAFLD group was significantly higher than that of the healthy control group.With the aggravation of pathological stages,the Young′s modulus value gradually increased(P<0.05).The ROC curve was drawn,and it was found that the area under the curve for the diagnosis of NAFLD by Young's modulus value was 0.8524,the diagnostic critical value was 5.732 kPa,the sensitivity was 81.05%,the specificity was 100%,and the Jordan index was 0.8105.The Young's modulus value also has a high differential diagnosis value for NAFLD in different pathologies of liver cirrhosis,liver fibrosis,and hepatitis.The areas under the curve are 0.9016,0.9964,and 0.9875,respectively.Conclusion:Ultrasound E imaging can increase the Young's modulus of NAFLD patients,which can be used for clinical diagnosis of NAFLD and differential diagnosis of different pathological stages.

关 键 词：超声E成像 非酒精性脂肪性肝病 病理分期 诊断 

分 类 号：R575[医药卫生—消化系统]