Lactobacillus plantarum CCFM8610 Alleviates Irritable Bowel Syndrome and Prevents Gut Microbiota Dysbiosis:A Randomized,Double-Blind,Placebo-Controlled,Pilot Clinical Trial  

作　　者：Yang Liu Xinjie Yu Leilei Yu Fengwei Tian Jianxin Zhao Hao Zhang Long Qian Qun Wang Zhengqing Xue Qixiao Zhai Wei Chen 

机构地区：[1]State Key Laboratory of Food Science and Technology,Jjiangnan University,Wixi 214122,China [2]School of Food Science and Technology,Jiangnan University,Wuxi 214122,China [3]Hwa Chong Institution(College),Singapore 269734,Singapore [4]International Joint Research Laborutory for Probiotics Jiangnan University,Wuxi 214122 China [5]National Engineering Research Center for Functional Food,Jjiangnan University,Wuxdi 214122,China [6]Wiuxi Translational Medicine Research Center and Jiangsu Translatianal Medicine Research Institute Wuxi Branch,Wixi 214122,China [7](Yangzhou)Institute of Food Biotechnology,Jiangnan University,Yangzhou 225004,China [8]The Tinghu People's Hospital,Yancheng 224002,China [9]Beijing Advanced Innnovation Center for Food Nutrition and Human Health,Beijing Technology and Rasiness Univesity(BTBU),Bejing 100048,China

出　　处：《Engineering》2021年第3期376-385,共10页工程（英文）

基　　金：supported by the National Natural Science Foun-dation of China Program(31871773 and 31820103010);National Key Research and Development Project(2018YFC1604206);Projects of Innovation and Development Pillar Program for Key Industries in Southern Xinjiang of Xinjiang Production and Construction Corps(2018DB002);National First-Class Discipline Program of Food Science and Technology(JUFSTR20180102);the Biotechnology and Biological Sciences Research Council(BBSRC) Newton Fund Joint Centre Award;Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province.

摘　　要：Irritable bowel syndrome with diarrhea(IBS-D)is chronic intestinal dysfunction with diarrhea and othercomplicated clinical symptoms,and it has a great impact on the daily life and mental state of patients.Some studies have reported that ingestion of probiotics can significantly alleviate a variety of intestinaldiseases.The pupose of this study was to investigate the IBS-D-alleviating effects of a probiotic strain,lactobacillus plantarum(L.plantarum)CCFM8610,with multiple health-promoting effects.The studywas a 12-week,randomized,double-blind,placebo-controlled,pilot clinical trial.Seventy-five patientswere randomly assigned to receive the placebo,oligosaccharides,or L.plantarum CCFM8610(1×10^(10) colony-forming units(CFU)per day),with a 2-week run-in period,an 8-week intervention period,anda 2-week follow-up observation period.The patients'clinical symptoms and quality of life were exam-ined by the IBS symptom severity scale(IBS-SsS)and the IlBS quality of life scale(IBS-QOL).Changes ingut microbiota composition and diversity were measured at the end of the intervention period.The oraladministration of L.plantarum CCFM8610 significantly decreased the IBS-SSS and IBS-QOL scores,reduced IBS-D symptom severity,recovered gut microbiota diversity,decreased the relative abundanceof bloating-related genus Methanobrevibacter,and increased the relative abundance of butyric acid-producing genera,including Anaerostipes,Anaerotruncus,Bifidobacterium,Butyricimonas,andOdoribacter.These findings suggest that ingestion of L.plantarum CCFM8610 can significantly alleviate clinical symptoms and gut microbiota dysbiosis in IBS-D patients.The IBS-D-alleviating effect of L.plan-tarum CCFM8610 may be related to theincrease in the relative abundance of butyric acid-producing genera in the intestine.

关 键 词：Lactobacillus plantarum Irritable bowelsyndrome Gut microbiota Butyric acid Clinical trial 

分 类 号：R574.4[医药卫生—消化系统]