肠道上皮样血管肉瘤2例临床病理观察  

Clinicopathological characteristics of intestinal epithelioid angiosarcoma:report of two cases

作　　者：张天铭 徐鹏飞 漆楚波[1] 岳君秋[1] 樊利芳 ZHANG Tian-ming;XU Peng-fei;QI Chu-bo;YUE Jun-qiu;FAN Li-fang(Department of Pathology,Hubei Cancer Hospital,Wuhan 430079,China)

机构地区：[1]湖北省肿瘤医院病理科,武汉430079

出　　处：《诊断病理学杂志》2021年第5期352-356,共5页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨肠道上皮样血管肉瘤临床病理特征、诊断、鉴别诊断及免疫组化表达特征。方法回顾性分析2例肠道上皮样血管肉瘤患者的临床病理资料,在光学显微镜下对其进行形态学观察,借助免疫组织化学进一步对上皮样血管肉瘤的特点进行分析。结果2例均发生在老年男性肠道。镜下见肿瘤细胞弥漫分布,瘤细胞呈上皮样形态,可见裂隙样结构及核旁空泡,空泡中可见红细胞。免疫组化,2例均表达CD31、ERG、Fli-1,其中1例CK点灶弱表达。结论肠道上皮样血管肉瘤是一种罕见的疾病,活检极易误诊为低分化癌等恶性肿瘤,正确的病理诊断是治疗的关键。Objective To explore the clinicopathological characteristics,diagnosis,differential diagnosis and immunohistochemical expression of intestinal epithelioid angiosarcoma.Methods The clinicopathological data of two patients with intestinal epithelioid angiosarcoma were analyzed retrospectively.Histomorphologic changes were observed under light microscope,and immunostaining was performed to explore the immunological characteristics of epithelioid angiosarcoma.Results Two cases were elderly men,and the lesion located at the intestine.Microscopically,the tumor cells were epithelial-like and distributed diffusely with fissure-like structures.Paranuclear vacuoles and red blood cells were visible in the vacuoles.Tumor cells were positive for CD31,ERG,Fli-1 in both cases,and CK was weakly expressed in one of them.Conclusion Epithelioid angiosarcoma of the digestive tract is very rare.As a poorly differentiated carcinoma,the diagnosis is based on surgical resection,which is easily misdiagnosed on biopsy.Correct diagnosis is important for precise treatment.

关 键 词：小肠 上皮样血管肉瘤 诊断 

分 类 号：R735.3[医药卫生—肿瘤]