高压氧联合罂粟碱治疗非坏疽性缺血性结肠炎的临床疗效  

Efficacy of hyperbaric oxygen combined with papaverine in the treatment of non-gangrenous ischemic colitis

作　　者：李松财 贝金币 曹春宇 Li Songcai;Bei Jinbi;Cao Chunyu(Department of Gastroenterology,Zhoushan Women and Children Hospital,Zhoushan 316000,China)

机构地区：[1]舟山市妇女儿童医院消化内科,浙江省舟山316000 [2]舟山市妇女儿童医院高压氧科,浙江省舟山316000

出　　处：《中华航海医学与高气压医学杂志》2021年第2期216-219,228,共5页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：舟山市科技计划项目(2017C31119)。

摘　　要：目的探讨高压氧联合罂粟碱治疗非坏疽性缺血性结肠炎的临床疗效。方法选取2018年1月至2019年6月舟山市妇女儿童医院消化内科收治的非坏疽性缺血性结肠炎患者94例,按随机数字表法将其分为高压氧治疗组和对照组,各47例。对照组采用常规对症支持治疗及罂粟碱治疗,高压氧治疗组采用常规对症支持治疗及高压氧联合罂粟碱治疗,2组均持续治疗2周。比较2组患者的临床指标、血液流变学指标、血清超氧化物歧化酶(SOD)活性、不良反应发生情况及临床疗效等。结果高压氧治疗组患者的腹痛缓解时间、压痛缓解时间、便潜血消失时间、肠功能恢复时间、住院时间等临床指标均短于对照组(P<0.01)。治疗2周后高压氧治疗组患者血液黏稠度和纤维蛋白原水平低于对照组,血清SOD活性高于对照组(P<0.01)。治疗过程中,2组患者胃肠道反应、过敏等不良反应差异均无统计学意义(P>0.05)。高压氧治疗组的总有效率高于对照组[95.74%(45/47)vs.80.85%(38/47)],差异有统计学意义(P<0.05)。结论高压氧联合罂粟碱治疗非坏疽性缺血性结肠炎能够改善临床指标和血液流变学指标,临床疗效明显,且具有较好的安全性。Objective To explore the effect of hyperbaric oxygen combined with papaverine in the treatment of non-gangrenous ischemic colitis.Methods A total of 94 cases of non-gangrenous ischemic colitis admitted to the Department of Gastroenterology of Zhoushan Women and Children Hospital from January 2018 to June 2019 were randomly divided into hyperbaric oxygen treatment group and control group with 47 cases in each group.The control group received conventional symptomatic supportive treatment and papaverine treatment,and the hyperbaric oxygen treatment group received conventional symptomatic supportive treatment and hyperbaric oxygen combined with papaverine treatment.Both two groups received continuous treatment for 2 weeks.The clinical indicators,hemorheological indicators,serum superoxide dismutase(SOD)activity,adverse reactions,and clinical efficacies of the two groups were compared.Results The clinical indicators such as the time to abdominal pain relief,the time to tenderness relief,the time to the disappearance of fecal occult blood,the time to intestinal function recovery,and the length of hospital stay,in the hyperbaric oxygen treatment group were significantly shorter than those in the control group(P<0.01).After 2 weeks of treatment,the blood viscosity and the level of blood fibrinogen in the hyperbaric oxygen treatment group were significantly lower than those in the control group(P<0.01),while the serum level of SOD was significantly higher than that in the control group(P<0.01).During the treatment,there was no significant difference in gastrointestinal reactions,allergies,or other adverse reactions between the two groups(P>0.05).The total effective rate of the hyperbaric oxygen treatment group was higher than that of the control group[95.74%(45/47)vs.80.85%(38/47)](P<0.05).Conclusion Hyperbaric oxygen combined with papaverine in the treatment of non-gangrenous ischemic colitis can improve the clinical indicators and hemorheological indicators,and achieve obvious clinical efficacy with a satisfactory safet

关 键 词：非坏疽性缺血性结肠炎 高压氧 罂粟碱 超氧化物歧化酶 

分 类 号：R574.62[医药卫生—消化系统]