农村地区40岁以上近视人群黄斑病变患病率及影响因素分析:邯郸眼病研究  

Prevalence and influencing factors of myopic maculopathy in myopic population aged 40 or more in rural area of China:Handan Eye Study

作　　者：曹凯[1] 林彩霞 胡爱莲[1] 杨晓慧[1] 王冰松[1] 张青[1] 胡健萍 郝洁[1] 张烨[1] 王宁利[1] 邯郸眼病研究课题组 Cao Kai;Lin Caixia;Hu Ailian;Yang Xiaohui;Wang Bingsong;Zhang Qing;Hu Jianping;Hao Jie;Zhang Ye;Wang Ningli;Handan Eye Study Group(Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing Tongren Hospital,Capital Medical University,Beijing 100005,China)

机构地区：[1]首都医科大学附属北京同仁医院、北京同仁眼科中心、北京市眼科研究所、眼科学与视觉科学北京市重点实验室,100005

出　　处：《眼科》2021年第3期177-183,共7页Ophthalmology in China

摘　　要：目的探索我国农村地区40岁以上人群的近视性黄斑病变患病率,并基于人工少数类过采样法(Synthetic Minority Over-Sampling Technique,SMOTE)探索近视性黄斑病变患病的影响因素。设计横断面研究。研究对象2012-2013年邯郸眼病研究中年龄在40岁及以上的近视人群1177例。方法通过问卷调查获取受试者的基本人口学资料及吸烟、饮酒等行为资料;通过体格检查获取受试者的身高、体重、血糖、血压等信息;通过实验室检查(采集血样)获取受试者的血液指标信息;采用“糖尿病视网膜病变早期治疗(Early Treatment Diabetic Retinopathy,EDTRS)”视力表测量受试者的生活视力和最佳矫正视力;采用Kowa压平眼压计(Tokyo,日本)测量眼压;采用Topcon自动验光仪(KR8800)测量屈光度;采用A超(10 MHz)对眼轴等生物学参数进行测量;采用Canon眼底相机(CR-2)分别拍摄以视盘和黄斑为中心的眼底照片各一张;近视性黄斑病变的阅片诊断方法:基于近视人群(等效球镜小于-0.5 D),眼底出现以下任意症状即判断为近视性黄斑病变:弥漫性脉络膜视网膜萎缩、斑片状脉络膜视网膜萎缩、黄斑萎缩、漆裂纹、后极部出现近视性脉络膜新生血管,Fuchs斑归类于近视性脉络膜新生血管中。采用我国第六次人口普查数据对近视性黄斑病变的患病率按年龄性别进行标准化;采用SMOTE算法对近视性黄斑病变资料的均衡性进行处理;采用Logistic回归探索近视性黄斑病变的影响因素;采用ROC曲线评估影响因素的预测效能。主要指标近视性黄斑病变的粗患病率及年龄-性别标准化患病率。结果在5055例有清晰可读眼底照片的40岁以上农村地区受试者中,1177例患有近视,其中35例患有近视性黄斑病变。在近视人群中,近视性黄斑病变的粗患病率为2.97%,年龄-性别标准化的患病率为2.65%。单因素分析结果显示:年龄(t=10.910,P<0.001)、教育程度(χ^(2)=21.5Objective To report the prevalence of myopic maculopathy in people over 40 years old in rural area of China,and to explore the influencing factors of myopic maculopathy based on Synthetic Minority Over-Sampling Technique(SMOTE)algorithm.Design Cross-sectional study.Participants 1177 myopia patients in the Handan Eye Disease Study from 2012 to 2013,aged 40 years and above.Methods Questionnaire was done to obtain subjects’basic demographic data and behavioral data such as smoking and drinking history;Subjects’height,weight and blood pressure were measured through physical examination;blood samples of each subject was collected for laboratory examinations;Early Treatment Diabetic Retinopathy(EDTRS)eye chart was used to measure the subject’s presenting visual acuity and best-corrected visual acuity(BCVA);Kowa applanation tonometer was used to measure the introcular pressure(IOP);Topcon automatic refractor(model KR8800)was used to measure diopter;A-ultrasound(10 MHz)was used to measure the eye axis and other biological parameters;use Canon fundus camera(model CR-2)to take two fundus photos that centered on the optic disc and the macula;the diagnosis method of maculopathy:based on the myopic population(spherical equivalent refraction less than-0.5 D),any of the following symptoms in the fundus was judged to be maculopathy:diffuse chorioretinal atrophy,patchy chorioretinal atrophy,macular atrophy,lacquer cracks,and myopic choroidal neovascularization appeared in the posterior pole.Fuchs spots were classified as myopic choroidal neovascularization.Using the sixth census data of China,the prevalence of maculopathy was graded and gender-standardized.The SMOTE algorithm was used to balance data.Logistic regression was used to explore the influencing factors of myopic maculopathy.the ROC curve was used to estimate the predictive power of the influencing factors.Main Outcome Measures Crude prevalence and age-sex standardized prevalence of maculopathy.Results Of the 5055 people over the age of 40 with clear-readable fund

关 键 词：近视性黄斑病变 患病率 影响因素 SMOTE算法 

分 类 号：R774.5[医药卫生—眼科]