45岁以上人群晶状体前表面拱高的测量及其与原发性闭角型青光眼的相关性:北京眼病研究  

Distribution of lens vault and its correlation with primary angle-closure glaucoma in people over 45 years old:Beijing Eye Study

作　　者：陈长喜[1] 曹凯[1] 王进达[1] 李建军[1] 徐亮[1] 王亚星[1] Chen Changxi;Cao Kai;Wang Jinda;Li Jianjun;Xu Liang;Wang Yaxing(Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Key Laboratory of OphtluiJmology and Visual Sciences,Beijing Tongren Hospital,Coital Medical University,Beijing 100005,China)

机构地区：[1]首都医科大学附属北京同仁医院、北京同仁眼科中心、北京市眼科研究所、眼科学与视觉科学北京市重点实验室,100005

出　　处：《眼科》2021年第3期200-203,共4页Ophthalmology in China

摘　　要：目的描述北京地区45岁以上人群的晶状体前表面拱高(lens vault,LV)的测量结果并探索其与原发性闭角型青光眼(primary angle closure glaucoma,PACG)的相关性。设计横断面调查。研究对象“北京眼病研究”5年随访人群2792例。方法对受试者进行屈光测量(电脑验光结合插片法)、眼压(非接触眼压计)、散瞳后裂隙灯数码眼前节照相、眼轴等生物学参数的测量(Lenstar)以及眼底照相。采用海德堡前节OCT拍摄照相并通过自带的软件对LV(晶状体的前极与两巩膜突水平连线的垂直距离)进行测量。问卷内容包括吸烟史、饮酒史,糖尿病及高血压病等既往病史。采用Logistic回归探索LV和PACG的相关性,采用比值比(odds ratios,OR)和95%置信区间(95%confidence interval,CI)评估关联强度。主要指标LV、OR值和95%CI。结果45岁以上人群的LV平均为(0.43±0.26)mm,男性平均为(0.38±0.28)mm,女性为(0.45±0.28)mm(t=4.76,P<0.001);45~54岁、55~64岁、65~74岁及≥75岁人群的LV分别为(0.33±0.26)mm、(0.42±0.27)mm、(0.48±0.29)mm和(0.58±0.29)mm,随着年龄的增长LV值有明显上升的趋势(F=7.84,P<0.001)。近视、正视和远视人群的LV分别为(0.26±0.31)mm、(0.43±0.26)mm和(0.56±0.26)mm,随着屈光状态从近视向远视变化,LV的水平也呈现上升趋势(F=4.86,P<0.001)。健康人群和PACG患者的LV分别为(0.42±0.28)mm和(0.84±0.25)mm(t=5.66,P<0.001),通过Logistic回归校正混杂因素后,OR值为1.022(95%CI:1.005,1.040)。结论北京地区45岁以上健康人群的LV值平均为(0.42±0.28)mm。LV随年龄增长而增大,女性高于男性,远视者高于近视者。较大的LV是PACG的患病危险因素。(眼科,2021,30:200-203)Objective To describe the characteristics of lens vault(lens vault,LV)in people over 45 years old in Beijing Eye Study and explore its correlation with primary angle closure glaucoma(PACG).Design Cross-sectional study.Participants 2792 subjects of 45-years old or more in 5-year followed population of Beijing Eye Study.Methods Detailed eye examinations were performed for the subjects,including refractive measurement,intraocular pressure(non-contact tonometer),digital anterior segment photography of slit lamp after mydriasis,and axis of the eye measurement of academic parameters(Lenstar)and fundus photography.The Heidelberg anterior segment OCT was used to take pictures and the LV(the vertical distance between the anterior pole of the lens and the horizontal line of the two scleral processes)was measured through the built-in software.The content of the questionnaire involved smoking history,drinking history,diabetes and hypertension and other medical history.Logistic regression was used to explore the correlation between LV and PACG,and odds ratios(OR)and 95%confidence interval(CI)were used to assess the strength of the association.Main Outcome Measures LV,OR value and 95%CI.Results The average LV level of people over 45 years old in Beijing Eye Study was 0.43±0.26 mm,the average LV level of men was 0.38±0.28 mm,and that of women was 0.45±0.28 mm(t=4.76,P<0.001).The LV levels of people 45~54 years old,55~64 years old,65~74 years old and≥75 years old are 0.33±0.26 mm,0.42±0.27 mm,0.48±0.29 mm and 0.58±0.29 mm,respectively,increasing with the increasing of age(F=7.84,P<0.001).The LV levels of myopia,emmetropia,and hyperopia were 0.26±0.31 mm,0.43±0.26 mm,and 0.56±0.26 mm,respectively.As the refractive status changed from nearsightedness to farsightedness,the LV level also showed an upward trend(F=4.86,P<0.001).The average LV levels of healthy people and PACG patients were 0.42±0.28 mm and 0.84±0.25 mm,respectively(t=5.66,P<0.001).Logistic regression showed the correlation between LV and PACG(OR=1.022;95

关 键 词：拱高 人群 前节OCT 闭角型青光眼 

分 类 号：R775.2[医药卫生—眼科]