NDI-induced Topological Conversion of Human Telomeric G-Quadruplexes from Hybrid-2 to Parallel Form  

作　　者：HAO Xueyu LI Chunjie WANG Yu ZHANG Feng HOU Jingwei KANG Chunqing GAO Lianxun 

机构地区：[1]Laboratory of Polymer Composite and Engineering,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,130022,P.R.China [2]University of Science and Technology of China,Hefei,230026,P.R.China

出　　处：《Chemical Research in Chinese Universities》2021年第3期795-800,共6页高等学校化学研究（英文版）

摘　　要：G-Quadruplexes(GQs),which are formed by G-rich DNA sequences in human telomeres,have become an attractive target for cancer treatment.The ligands to stabilize the conformation of human telomeric GQs in vivo are particularly important for structure-based ligand design and drug development targeting the noncanonical DNA structure.Here we report the conformational conversion of Tel26 induced by a naphthalene diimide(NDI)ligand in K^(+)buffer,even at cellular physiological temperature(37℃)and under mimetic cellular crowding conditions created by Ficoll 70.We provide an insight into the dynamic conversion from initial hybrid-2 GQ topology to final parallel GQ topology.These results are helpful for the design of ligands with GQ conformation regulation.

关 键 词：G-QUADRUPLEX Naphthalene diimide Topological conversion Telomeric DNA 

分 类 号：O62[理学—有机化学]