自噬调控消化道肿瘤生长的研究进展  

Research progress of autophagy in digestive tract tumors

作　　者：何玉鑫 张尤历[1] 李非凡 徐岷[1] HE Yuxin;ZHANG Youli;LI Feifan;XU Min(Department of Gastroenterology,the Affiliated Hospital of Jiangsu University,Zhenjiang 212000,China)

机构地区：[1]江苏大学附属医院消化内科,江苏镇江212000

出　　处：《胃肠病学和肝病学杂志》2021年第6期713-717,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金(81672402);江苏省重点研发计划-社会发展(BE2018689);江苏省自然科学基金(BK20171305);江苏省医学重点人才项目(ZDRCC2016026);江苏省高层次卫生人才“六个一工程”科研项目(LGY2016054)。

摘　　要：自噬是一种细胞分解自身成分的过程,它参与了细胞稳态的维持。在消化道肿瘤发生发展的过程中自噬起着抑制或促进的双重作用,激活或阻断自噬会干扰肿瘤的生长,这可能成为肿瘤治疗的新靶点。本文将从致癌基因清除、免疫应答、细胞死亡、代谢调节、压力适应、恶性转化、治疗抵抗等方面分析自噬对消化道肿瘤生长的影响。Autophagy is a process in which cells decompose their own components,which participates in the maintenance of cell homeostasis.Autophagy plays a dual role of inhibition or promotion in the occurrence and development of digestive tract tumors.Activating or blocking autophagy will interfere with tumor growth,which may become a new target for tumor therapy.In this paper,we will analyze the effect of autophagy on digestive tract tumor growth from the aspects of oncogene clearance,immune response,cell death,metabolic regulation,pressure adaptation,malignant transformation,treatment resistance and so on.

关 键 词：自噬 消化道肿瘤 生长调控 

分 类 号：R735[医药卫生—肿瘤]