Deformable double-shelled hollow mesoporous organosilica nanocapsules:A multi-interfacial etching strategy  

作　　者：Zhihao Feng Zhaogang Teng Yuyuan Shi Wenhui Shi Xiaodan Su Guangming Lu Lianhui Wang Lixing Weng 

机构地区：[1]Key Laboratory for Organic Electronics&Information Displays and Jiangsu Key Laboratory for Biosensors,Institute of Advanced Materials,Jiangsu National Synergetic Innovation Centre for Advanced Materials,Nanjing University of Posts and Telecommunications(NJUPT),Nanjing 210023,China [2]College of Geography and Biological Information,Nanjing University of Posts and Telecommunications,Nanjing 210046,China [3]Department of Medical Imaging,Jinling Hospital,School of Medicine,Nanjing University,Nanjing 210002,China

出　　处：《Chinese Chemical Letters》2021年第3期1101-1105,共5页中国化学快报（英文版）

基　　金：financially supported by the National Key Research and Development Program of China(Nos.2017YFA0205301,2017YFA0205302);the Key Research and Development Program of Jiangsu(No.BE2018732);the National Natural Science Foundation of China(Nos.81971675,21603106);the Natural Science Foundation of Jiangsu Province(No.BK20160017);the State Key Laboratory of Analytical Chemistry for Life Science(No.5431ZZXM1717)。

摘　　要：Multishelled hollow structures have drawn increasing interest because of their peculiar compartmentation environments and physicochemical properties.In this work,deformable double-shelled hollow mesoporous o rganosilica nanocapsules(DDHMONs)were succes s fully synthesized by a multi-interfacial etching strategy.The obtained DDHMONs have a double-shelled structure with aninorganic-organic hybrid framework,a uniform outer layer(~320 nm)and inner layer(~180 nm),ordered mesochannels(~2.21 nm),and a large specific surface area(~1233 m^(2)/g).In vitro toxicity tests show that the DDHMONs have excellent biocompatibility when coincubated with human breast cancer cells.In addition,the anti cancer substance doxorubicin(DOX)can be highly loaded in DDHMONs(~335μg/mg).The results from flow cytometry together with confocal laser scanning microscopy show that DOX can be efficiently delivered into MCF-7 cells by DDHMONs,thus improving chemotherapeutic efficiency and demonstrating that DDHMONs have potential nanomedicine applications as anticancer agents.

关 键 词：Hollow structure MESOPOROUS Double-shelled ORGANOSILICA ANTICANCER 

分 类 号：TQ460.4[化学工程—制药化工] TB383.1[一般工业技术—材料科学与工程]