新发难治性癫痫持续状态研究进展  

Research progress of new-onset refractory status epilepticus

作　　者：杨继鲜 周心连 杨云凤 雷春艳 钟莲梅[1] Yang Jixian;Zhou Xinlian;Yang Yunfeng;Lei Chunyan;Zhong Lianmei(Department of Neurology,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院神经内科,650032

出　　处：《中华神经科杂志》2021年第6期607-611,共5页Chinese Journal of Neurology

基　　金：国家自然科学基金(81960251)。

摘　　要：新发难治性癫痫持续状态是一种罕见且高病死率的特殊临床表现,约一半以上的患者无法明确病因。目前该病的发病机制不清楚,治疗方案仍存在争议。近年研究发现机体炎性及免疫性反应可能参与致病过程,并基于发病机制角度将其称为“炎性-免疫性介导的癫痫性脑病”。也有研究尝试基于炎性及免疫性机制的治疗方法,部分取得满意疗效,但多基于小样本病例回顾,目前仍缺乏相关指南。文中就目前对新发难治性癫痫持续状态的定义、病因及发病机制、临床表现及治疗方案作一综述。New-onset refractory status epilepticus is a rare and special clinical manifestation with high mortality.About half of the patients have no clear cause.At present,the pathogenesis is unclear,and the treatment plan is controversial.In recent years,it has been found that inflammatory and immune responses of the body may be involved in the pathogenic process,and it is called“inflammatory-immune mediated epileptic encephalopathy”based on the perspective of pathogenesis.There have also been many treatment attempts based on the inflammatory and immunological mechanisms,some of which have achieved satisfactory results.However,most of them are based on the review of small sample cases,and relevant guidelines are still lacking at present.In this paper,the definition,etiology,pathogenesis,clinical manifestations and treatment of persistent status of new-onset refractory status epilepticus are reviewed.

关 键 词：癫痫持续状态 神经系统自身免疫疾病 诊断 治疗学 

分 类 号：R742.1[医药卫生—神经病学与精神病学]