帕金森病的语音特征及功能影像研究进展  

The research progress of speech feature and functional image in Parkinson′s disease

作　　者：邹潇雅 承欧梅[1] Zou Xiaoya;Cheng Oumei(Department of Neurology,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院神经内科,400016

出　　处：《中华神经科杂志》2021年第6期620-625,共6页Chinese Journal of Neurology

基　　金：国家自然科学基金(81871002)。

摘　　要：言语障碍是帕金森病患者运动障碍最早出现的症状之一,甚至出现在肢体运动障碍之前。患者的生活质量会因为言语障碍的存在和严重程度受到显著的影响,针对帕金森病言语障碍的早期识别就显得尤为必要,而声学分析的异常在帕金森病的早期就已经发生。语音在声学分析上表现出了特征性的改变,有助于帕金森病的诊断。与此同时,这些特征与功能影像的相关性还不是很明确。文中主要阐述了帕金森病患者的语音特征及其功能影像上的改变,进一步揭示其言语障碍的发生机制,并为帕金森病的诊断及鉴别诊断提供线索。Speech disorders are the earliest sign of motor impairment in Parkinson′s disease(PD),even before limb dyskinesia.Patient′s quality of life can be affected significantly by the presence and severity of speech pathology.The early diagnosis is particularly necessary for PD with speech disorders.The abnormal phenomena in acoustic analysis have occurred in the early stage of PD.The voice of PD patients manifests characteristic changes on acoustic analyses,which is helpful for the diagnosis of PD,while the neural correlation of these features are not clear.In this paper,the speech features and functional imaging changes of patients with PD are described,and the mechanism of speech disorders is further revealed,and clues for the diagnosis and differential diagnosis of PD are provided.

关 键 词：帕金森病 言语障碍 言语声学 磁共振成像 综述 

分 类 号：R742.5[医药卫生—神经病学与精神病学]