磁感应热疗作用于胆管癌模型热场分布的研究  

Study on the thermal field distribution of cholangiocarcinoma model by magnetic fluid hyperthermia

作　　者：蔡忠祥 逯迈 CAI Zhongxiang;LU Mai(Key Laboratory of Optoelectronic Technology and Intelligent Control Ministry of Education,Lanzhou Jiaotong University,Lanzhou 730070,P.R.China)

机构地区：[1]兰州交通大学光电技术与智能控制教育部重点实验室,兰州730070

出　　处：《生物医学工程学杂志》2021年第3期528-538,548,共12页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(51867014,51567015);甘肃省教育厅项目(2018D-08)。

摘　　要：胆管癌是一种恶性程度很高的肿瘤,对放疗、化疗不敏感,预后较差,而当前尚缺乏有效的治疗手段。磁感应热疗作为一种治疗癌症的新方法,近年来在临床上已经应用于多种癌症,本文将其引入胆管癌模型,系统地研究了磁感应热疗作用于胆管癌时的效果。从磁流体发热理论出发,采用Pennes生物传热方程,在有限元仿真软件COMSOL中构建了电磁和传热模型。使用亥姆霍兹线圈作为热疗的交变磁场发生装置,根据Rosensweig的理论分析了磁流体相关性质与发热功率的关系,进行多物理场耦合仿真后,得到了热疗区域的电磁场和热场分布。结果表明:治疗区域磁场分布均匀,热场分布符合热疗要求。注射磁流体后的胆管癌组织升温迅速,肿瘤组织均能达到42℃以上,而周围健康组织升温不明显。同时验证了胆管周围的大血管、磁流体的溢出和涡流热对热疗的影响较小。本文结果可为胆管癌的磁感应热疗临床应用提供参考。Cholangiocarcinoma is a highly malignant tumor.It is not sensitive to radiotherapy and chemotherapy and has a poor prognosis.At present,there is no effective treatment.As a new method for treating cancer,magnetic fluid hyperthermia has been clinically applied to a variety of cancers in recent years.This article introduces it to the cholangiocarcinoma model and systematically studies the effect of magnetic fluid hyperthermia on cholangiocarcinoma.Starting from the theory of magnetic fluid heating,the electromagnetic and heat transfer models were constructed in the finite element simulation software COMSOL using the Pennes biological heat transfer equation.The Helmholtz coil was used as an alternating magnetic field generating device.The relationship between the magnetic fluid-related properties and the heating power was analyzed according to Rosensweig’s theory.After the multiphysics coupling simulation was performed,the electromagnetic field and thermal field distribution in the hyperthermia region were obtained.The results showed that the magnetic field distribution in the treatment area was uniform,and the thermal field distribution met the requirements of hyperthermia.After the magnetic fluid injection,the cholangiocarcinoma tissue warmed up rapidly,and the temperature of tumor tissues could reach above 42℃,but the surrounding healthy tissues did not heat up significantly.At the same time,it was verified that the large blood vessels around the bile duct,the overflow of the magnetic fluid,and the eddy current heat had little effect on thermotherapy.The results of this article can provide a reference for the clinical application of magnetic fluid hyperthermia for cholangiocarcinoma.

关 键 词：胆管癌 肿瘤 磁感应热疗 有限元分析 磁性纳米粒子 

分 类 号：R730.5[医药卫生—肿瘤] R735.8[医药卫生—临床医学]