维生素D在自身免疫性肝病中的研究进展  

Progress in research on vitamin D in autoimmune liver disease

作　　者：段金楠 蔡群 王浩[1] 盛吉芳[1] DUAN Jin-nan;CAI Qun;WANG Hao;SHENG Ji-fang(State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310003,China)

机构地区：[1]浙江大学医学院附属第一医院传染病诊治国家重点实验室国家感染性疾病临床医学研究中心感染性疾病诊治协同创新中心,浙江杭州310003

出　　处：《中国微生态学杂志》2021年第5期614-617,F0003,共5页Chinese Journal of Microecology

摘　　要：维生素D是一种人体必需的脂溶性维生素,其除了可调节钙磷代谢,参与骨骼生长外,还可通过调节免疫细胞增殖分化和抗炎抗纤维化等参与多种免疫性疾病的发生发展。自身免疫性肝病(autoimmune liver disease, AILD)是由自身免疫反应引起的一组肝脏炎症性病变,有研究发现维生素D与AILD存在相关性,AILD患者血清中维生素D水平普遍降低,补充血清维生素D可降低肝损伤和肝纤维化程度。因此,探究维生素D在AILD发生发展中的作用具有一定的临床价值。本文对维生素D在AILD中的研究进展作一阐述。Vitamin D is an essential fat soluble vitamin for human body. It can regulate calcium and phosphorus metabolism, and participate in bone growth. It also participates in the occurrence and development of a variety of immune diseases by regulating the proliferation and differentiation of immune cells, and exerting anti-inflammatory and anti-fibrotic effects. Autoimmune liver disease(AILD) is a group of liver inflammatory diseases caused by autoimmune reaction. It has been observed that there is a correlation between vitamin D and AILD as serum vitamin D level in AILD is generally reduced, and supplement of serum vitamin D can reduce the degree of liver injury and liver fibrosis. Therefore, it is of clinical significance to explore the role of vitamin D in AILD. This article reviews the progress in research on vitamin D in AILD.

关 键 词：维生素D 自身免疫性肝病 原发性胆汁性胆管炎 原发性硬化性胆管炎 自身免疫性肝炎 

分 类 号：R575.1[医药卫生—消化系统]