副乳癌和常规胸部乳腺癌HES1、HER2表达差异及临床病理特征分析  

Differential expression of HES1 and HER2 and analysis of clinicopathological features between accessory breast cancer and routine mammary cancer

作　　者：宋天豹 王建军[1] 孙小虎 王保信[1] 陈绍华[1] 李国明[1] 吕建男 SONG Tian-bao;WANG Jian-jun;SUN Xiao-hu;WANG Bao-xin;CHEN Shao-hua;LI Guo-ming;LÜJian-nan(Department of Breast Surgery,Central Hospital of China National Petroleum Corporation,Langfang Hebei 065000,China)

机构地区：[1]中国石油天然气集团公司中心医院乳腺外科,河北廊坊65000

出　　处：《蚌埠医学院学报》2021年第5期611-615,共5页Journal of Bengbu Medical College

基　　金：河北省廊坊市科学技术研究与发展计划项目(2018013156)。

摘　　要：目的:探讨副乳癌(ABC)和常规胸部乳腺癌(MC)转录因子发状分裂相关增强子1(HES1)、人类表皮生长因子受体2(HER2)表达差异及其与临床病理特征的关系。方法:回顾性分析30例ABC和30例MC病人的临床资料、病理资料和肿瘤组织HES1、HER2表达情况及随访资料,并进行统计分析。结果:ABC组HES1、HER2阳性表达率分别为30.00%、53.33%,MC组为40.00%、40.00%,2组HES1和HER2阳性率差异均无统计学意义(P>0.05)。ABC组和MC组病人HES1阳性表达率在不同病理类型、组织学分级、临床分期和是否淋巴结转移、三阴乳腺癌间差异均有统计学意义(P<0.05~P<0.01),ABC组HES1阳性表达率在是否复发病人间差异亦有统计学意义(P<0.05)。ABC病人HER2阳性表达率在不同病理类型、组织学分级、临床分期和是否三阴乳腺癌及复发间差异均有统计学意义(P<0.05~P<0.01);MC病人HER2阳性表达率在不同病理类型、临床分期和是否淋巴结转移、三阴乳腺癌间差异均有统计学意义(P<0.01)。结论:术前HES1、HER2阳性表达率可一定程度上反映ABC、MC病人病理特征,为合理手术方案的选择提供参考。Objective:To investigate the differences in the expression of hairy and enhancer of split 1(HES1)and human epidermal growth factor receptor 2(HER2)in accessory breast cancer(ABC)and routine mammary cancer(MC)and their relationship with clinicopathological features.Methods:The clinical data,pathological data,expression of HES1 and HER2 in cancer tissues and follow-up data of 30 patients with ABC and 30 patients with MC were analyzed retrospectively and evaluated statistically.Results:The positive expression rates of HES1 and HER2 in ABC group were 30.00%and 53.33%,respectively,which were 40.00%and 40.00%in MC group,respectively,and the difference of which was not statistically significant(P>0.05).There were significant differences in the positive expression rate of HES1 between ABC group and MC group in different pathological type,histological grades,clinical stage,lymph node metastasis and triple negative breast cancer(P<0.05 to P<0.01).The positive expression rate of HES1 in ABC group was also statistically significant between patients with recurrence or not(P<0.05).The positive expression rate of HER2 in ABC patients was statistically significant among different pathological type,histological grade,clinical stage,triple negative breast cancer and recurrence or not(P<0.05 to P<0.01).The positive expression rate of HER2 in MC patients was statistically significant among different pathological type,clinical stage,lymph node metastasis or not and triple negative breast cancer(P<0.01).Conclusions:The positive expression rates of HES1 and HER2 before surgery can reflect the pathological features of ABC and MC patients to a certain extent,and provide reference for the selection of reasonable surgical plans.

关 键 词：乳腺肿瘤 转录因子发状分裂相关增强子1 人类表皮生长因子受体2 

分 类 号：R737.9[医药卫生—肿瘤]