不同程度老年痴呆病人睡眠障碍特征的研究  

Study on the characteristics of sleep disorders in the elderly patients with dementia

作　　者：周恩竹 夏丽[1] 吕洋[1] 刘欣彤[1] ZHOU En-zhu;XIA Li;LYU Yang;LIU Xin-tong(Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China)

机构地区：[1]重庆医科大学附属第一医院老年病科,重庆市400016

出　　处：《实用老年医学》2021年第6期599-601,共3页Practical Geriatrics

摘　　要：目的研究不同程度老年痴呆病人的睡眠障碍特征。方法纳入2016~2019年于重庆医科大学附属第一医院老年病科住院的老年痴呆病人752例,根据MMSE得分及文化程度分为认知正常组411例、认知障碍组341例,认知障碍组进一步被分为轻度痴呆组133例(21~26分)、中度痴呆组167例(10~20分)、重度痴呆组41例(<10分)。比较4组的匹兹堡睡眠质量指数(PSQI)总分及各因子得分情况。结果认知障碍组PSQI总分高于正常组(P<0.05),其中前者入睡潜伏时间、睡眠效率及日间功能障碍得分高于后者(P<0.05)。轻、中、重度痴呆组PSQI总分依次递增。中、重度痴呆组的日间功能障碍得分均高于轻度痴呆组(P<0.05)。重度痴呆组的入睡潜伏时间、睡眠效率、日间功能障碍得分均高于轻度和中度痴呆组(P<0.05)。结论认知障碍病人睡眠障碍问题更加严重,且随着痴呆程度的加深,睡眠障碍也随之加重;痴呆程度对睡眠障碍特征的影响由以日间功能障碍为主,逐渐进展到入睡潜伏时间、睡眠效率、日间功能障碍均受累。Objective To investigate the characteristics of sleep disorders in the elderly patients with different degrees of dementia.Methods A total of 752 elderly patients were enrolled from the Department of Geriatrics in the First Affiliated Hospital of Chongqing Medical University from 2016 to 2019.The patients were divided into normal cognition group(n=411)and dementia group(n=341)according to the score of Mini-Mental State Examination(MMSE).The dementia group was further divided into three groups as mild group(n=133,21-26 scores),moderate group(n=167,10-20 scores)and severe group(n=41,0-9 scores).The scores of Pittsburgh Sleep Qualit Index(PSQI)scales of the four groups were analyzed and compared.Results The total score of PSQI and the scores of sleep onset,sleep efficiency and day function disorder were significantly higher in dementia group than those in normal cognition group(P<0.05).The total score of PSQI was generally increased with the increase of the degree of dementia(P<0.05).The score of day function disorder in the the mild group was less than that in the other two groups(P<0.05),while the scores of sleep onset,sleep efficiency and day function disorder in severe group were higher than those in mild group and moderate group(P<0.05).Conclusions The patients with dementia present with sleep disorders which is associated with the degree of dementia.Day function is affected at the early stage of dementia,followed by sleep onset and sleep efficiency.

关 键 词：痴呆 睡眠障碍 认知障碍 痴呆程度 临床特征 老年人 

分 类 号：R749.1[医药卫生—神经病学与精神病学]