骨桥蛋白在缺血性脑卒中发病中脑保护作用机制的研究进展  

Research progress on the protective mechanism of osteopontin in ischemic stroke

作　　者：郭群 任晓玉 张琦[1] 聂木兰 徐璐 龙倩梅 郭一凡 王东[2] 刘斌[3] 何玮 金银川 GUO Qun;REN Xiao-yu;ZHANG Qi;NIE Mu-lan;XU Lu;LONG Qian-mei;GUO Yi-fan;WANG Dong;LIU Bin;HE Wei;JIN Yin-chuan(Binzhou Medical University,Yantai,264000,Shandong,China;Affiliated Hospital of Binzhou Medical University,Binzhou,256600,Shandong,China;the Fourth Military Medical University,Xian,710000,Shaanxi,China)

机构地区：[1]滨州医学院,山东烟台264000 [2]滨州医学院附属医院,山东滨州256600 [3]第四军医大学,陕西西安710000

出　　处：《海南医学院学报》2021年第12期950-955,共6页Journal of Hainan Medical University

基　　金：国家自然科学基金青年项目(81701301);大学生创新训练项目-国家级(20022901043)。

摘　　要：缺血性脑卒中是全球范围内居民死亡、致残的重要原因,目前的主要治疗方法是溶栓、取栓等,然而有大量患者错过溶栓、取栓窗口期或者有其他不适宜溶栓的情况,故需要脑保护药物或生物活性物质来保护神经组织、改善预后,但是目前仍缺乏强有效的药物或生物活性物质以供选择。骨桥蛋白(osteopontin,OPN)是一种磷酸化糖蛋白,通过与细胞整合素受体结合、诱导信号传递等途径,在细胞粘连、分化、存活及修复等诸多方面产生重要作用。众多研究表明,在缺血性脑卒中发病中,骨桥蛋白可以通过抗炎、促血管新生、促神经干细胞迁移等多种方式保护脑组织,减轻缺血性脑卒中引起的脑损伤。Ischemic stroke has become an important cause of death and disability for residents worldwide.At present,the main treatment methods are thrombolysis and embolectomy.However,a large number of patients miss the window period of thrombolysis and embolectomy or have other conditions that are not suitable for thrombolysis.Therefore,cerebral protective drugs or bioactive substances are needed to protect neural tissue and improve the prognosis of the patients.However,there is still a lack of effective drugs or bioactive substances for selection.Osteopontin(OPN)is a phosphorylated glycoprotein that plays an impor-tant role in cell adhesion,differentiation,survival and repair by binding to cellular integrin receptors and inducing signal transmis-sion.Numerous studies have shown that osteopontin can protect brain tissue and reduce brain injury caused by ischemic stroke through various means such as promoting angiogenesis and neural stem cell migration in the pathogenesis of ischemic stroke.

关 键 词：缺血性脑卒中 骨桥蛋白 RGD序列 脑保护作用 

分 类 号：R743.3[医药卫生—神经病学与精神病学]