尿崩症并垂体柄增粗2例  

Report of 2 cases of diabetes insipidus and pituitary stalk thickening

作　　者：吴远 高楚淇 马晓群 文娟 崔莉 朱本章 吴晓燕 王毅[1] Yuan WU;Chu-Qi GAO;Xiao-Qun MA;Juan WEN;Li CUI;Ben-Zhang ZHU;Xiao-Yan WU;Yi WANG(Department of Endocrinology,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China;Department of Endocrinology,Wuzhong City People's Hospital,Wuzhong 750000,Ningxia Province,China;Department of Internal Medicine,Xunyang County Hospital,Ankang 725700,Shaanxi Province,China;Department of Endocrinology,Gansu Jiugang Hospital,Jiayuguan 735100,Gansu Province,China)

机构地区：[1]西安交通大学第一附属医院内分泌代谢科,西安710061 [2]吴忠市人民医院内分泌科,宁夏吴忠750000 [3]旬阳县医院内一科,陕西安康725700 [4]甘肃酒钢医院内分泌科,甘肃嘉峪关735100

出　　处：《医学新知》2021年第3期231-236,共6页New Medicine

基　　金：陕西省创新能力支撑计划(2020KRM171)。

摘　　要：本文分析2例尿崩症并垂体柄增粗(pituitary stalk thickening,PST)患者的临床资料并复习文献。2例患者分别为16岁男性和13岁女性,均有多饮、多尿症状,垂体磁共振成像提示PST。垂体前后叶功能评价显示均为中枢性尿崩症,后者同时合并垂体前叶功能减退症。2例均行垂体柄活检术,病理诊断分别为朗格汉斯组织细胞增生症和垂体生殖细胞瘤。PST是中枢性尿崩症患者最常见的影像学表现之一,提示炎性或肿瘤性疾病的浸润,病变性质的鉴别是垂体柄增粗诊疗的关键,垂体活检是病因诊断的金标准。To analyze the clinical data of 2 patients with diabetes insipidus(DI)who had pituitary stalk thickening(PST)and review the literature.The 2 patients were a 16-year-old boy and a 13-year-old girl who presented with complaints of thirst and polyuria.Both pituitary MRIs suggested PST.The boy had central diabetes insipidus(CDI),while the girl had both CDI and anterior pituitary dysfunction(APD).Langerhans’cell histiocytosis(LCH)and germinoma were diagnosed pathologically by pituitary stalk biopsy.PST is one of the most common clinical imaging manifestation in CDI patients suggesting inflammatory or neoplastic infiltration.The differential diagnosis of PST-related diseases is important in clinical practice with pituitary biopsy being the gold standard for diagnosis.

关 键 词：尿崩症 垂体柄增粗 郎格汉斯细胞组织细胞增生症 

分 类 号：R736.4[医药卫生—肿瘤]