Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling  

作　　者：Hongyuan Li Yinghua Peng Cong Lin Xiaozheng Zhang Tianshu Zhang Yibo Wang Yuanpeng Li Siru Wu Hongshuang Wang Mark RHutchinson Linda RWatkins Xiaohui Wang 

机构地区：[1]Laboratory of Chemical Biology,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Jilin 130022,China [2]Institute of Special Animal and Plant Sciences,Chinese Academy of Agricultural Sciences,Jilin 130112,China [3]Discipline of Physiology,Adelaide Medical School,University of Adelaide,Adelaide,SA,Australia [4]Department of Psychology and Neuroscience,and the Center for Neuroscience,University of Colorado at Boulder,Boulder,CO 80309,USA [5]Department of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China [6]ARC Centre of Excellence for Nanoscale Biophotonics,University of Adelaide,Adelaide,SA 5000,Australia

出　　处：《The Innovation》2021年第2期139-147,共9页创新（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(91956121,21877106,21807098,and 21850410455);the Chinese Academy of Sciences(CAS)Pioneer Hundred Talents Program,the Young Talents Program of the Chinese Academy of Agricultural Sciences,and the Natural Science Foundation of Jilin Province(20180101021JC);Computing time was supported by the Network and Computing Center,Changchun Institute of Applied Chemistry,CAS,the National Supercomputing Center in Guangzhou,and the National Supercomputing Center in Shenzhen.M.R.H.is the recipient of an ARC Future Fellowship(FT180100565);Director of the Australian Research Council Centre of Excellence for Nanoscale BioPhotonics(CE140100003).

摘　　要：Nicotine is the principal alkaloid of tobacco often manufactured into cigarettes and belongs to a highly addictive class of drugs.Nicotine attenuates the neuroinflammation induced by microglial activation.However,the molecular target(s)underlying anti-inflammatory action of nicotine has not been fully understood.Considering the psychoactive substances morphine,cocaine,and methamphetamine act as xenobiotic-associated molecular patterns and can be specifically sensed by the innate immune receptor Toll-like receptor 4(TLR4),here we sought to delineate whether nicotine and/or its metabolite cotinine may be recognized by the innate immune system via myeloid differentiation protein 2(MD2).

关 键 词：belongs ALKALOID system 

分 类 号：O62[理学—有机化学]