保乳术结合新辅助化疗法治疗乳腺癌的疗效分析  

Analysis of the Curative Effect of Breast-conserving Surgery Combined with Neoadjuvant Chemotherapy in the Treatment of Breast Cancer

作　　者：单孝军[1] 张艳 张丽君[1] 韩超 王红岩[1] SHAN Xiaojun;ZHANG Yan;ZHANG Lijun;HAN Chao;WANG Hongyan(Department of General Surgery,Daqing Oilfield General Hospital of Heilongjiang Province,Daqing,Heilongjiang Province,163001 China)

机构地区：[1]黑龙江省大庆油田总医院普外三科,黑龙江大庆163001

出　　处：《系统医学》2021年第8期150-152,共3页Systems Medicine

摘　　要：目的探讨保乳术结合新辅助化疗法应用在乳腺癌患者中的临床治疗效果。方法选取2018年1月—2019年8月的乳腺癌患者80例为该次的研究对象,将患者采用数字随机法进行分组,分为观察组和对照组,每组40例,对于对照组患者改良根治术治疗,对于观察组实施保乳术结合新辅助化疗法治疗,对两组患者的疗效进行比较。结果在采取不同的治疗措施之后,观察组患者的手术时间为(48.56±7.56)min,对照组为(75.56±17.56)min,差异有统计学意义(t=8.193,P<0.05),术中出血量分别为(107.56±7.54)、(219.54±22.56)mL,差异有统计学意义(t=29.766,P<0.05),住院天数为(3.68±0.68)、(7.94±1.37)d,差异有统计学意义(t=17.615,P<0.05),效果明显高于对照组患者,差异有统计学意义(P<0.05)。而比较两组患者的生存率,观察组为95.0%,对照组为92.5%,差异无统计学意义(χ2=0.000,P>0.05),复发率10.0%、7.5%,差异无统计学意义(χ2=0.000,P>0.05),转移率12.5%、15.0%,两组患者之间差异无统计学意义(χ2=0.000,P>0.05)。比较躯体状况,观察组为(17.52±2.45)分,对照组是(18.85±2.25)分,差异有统计学意义(t=2.579,P<0.05),功能状况分别为(10.25±1.52)分、(11.53±1.61)分,差异有统计学意义(t=3.656,P<0.05),情绪状况(17.25±2.36)分、(19.41±2.31)分,差异有统计学意义(t=4.136,P<0.05),社会及家庭状分别为(19.64±2.31)分、(22.31±2.14)分,差异有统计学意义(t=5.362,P<0.05),观察组患者要优于对照组,差异有统计学意义(P<0.05)。结论在乳腺癌患者中应用保乳术结合新辅助化疗法进行治疗,可以有效提高患者的生活质量,效果显著,值得临床推广。Objective To explore the clinical effect of breast conserving surgery combined with neoadjuvant chemotherapy in breast cancer patients.Methods Selected 80 breast cancer patients from January 2018 to August 2019 as the research objects.The patients were divided into observation group and control group by number randomization,each with 40 cases,and the improvement of the control group for radical mastectomy,breast-conserving surgery combined with neoadjuvant chemotherapy was implemented for the observation group,and the efficacy of the two groups of patients was compared.Results After taking different treatment measures,the operation time of the observation group was(48.56±7.56)min and the control group was(75.56±17.56)min,the difference was statistically significant(t=8.193,P<0.05),and the amount of intraoperative blood loss was respectively were(107.56±7.54)mL,(219.54±22.56)mL,the difference was statistically significant(t=29.766,P<0.05),the hospital stay was(3.68±0.68)d,(7.94±1.37)d,the difference was statistically significant(t=17.615,P<0.05),the treatment effect of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).Comparing the survival rates of the two groups of patients,the observation group was 95.0%,the control group was 92.5%,the difference was not statistically significant(χ2=0.000,P>0.05),the recurrence rate was 10.0%,7.5%,and the difference was not statistically significant(χ2=0.000,P>0.05),the transfer rate was 12.5%,15.0%,there was no statistically significant difference between the two groups of patients(χ2=0.000,P>0.05).Comparing the physical condition,the observation group was(17.52±2.45)points and the control group was(18.85±2.25)points,the difference was statistically significant(t=2.579,P<0.05),and the functional status was(10.25±1.52)points and(11.53±1.61)points,the difference was statistically significant(t=3.656,P<0.05),emotional state(17.25±2.36)points,(19.41±2.31)points,the difference was statis

关 键 词：保乳术 新辅助化疗法 乳腺癌 

分 类 号：R737[医药卫生—肿瘤]