尼莫地平联合血塞通注射液对蛛网膜下腔出血术后脑血管痉挛、血流速度及神经功能的影响  

Effects of Nimodipine Combined with Xuesaitong Injection on Cerebral Vasospasm,Blood Flow Velocity and Nerve Function after Subarachnoid Hemorrhage

作　　者：孙爱芹 王玉治[2] 宋新峰 夏建光[1] 张军普[2] SUN Aiqin;WANG Yuzhi;SONG Xinfeng;XIA Jianguang;ZHANG Junpu(Department of Critical Care Medicine,Dezhou People's Hospital,Dezhou,Shandong Province,253000 China;Department of Neurosurgery,Dezhou People's Hospital,Dezhou,Shandong Province,253000 China;School of Medicine and Nursing,Dezhou University,Dezhou,Shandong Province,253000 China)

机构地区：[1]德州市人民医院重症医学科,山东德州253000 [2]德州市人民医院神经外科,山东德州253000 [3]德州学院医药与护理学院,山东德州253000

出　　处：《系统医学》2021年第8期159-161,共3页Systems Medicine

摘　　要：目的探讨尼莫地平联合血塞通注射液对蛛网膜下腔出血术后脑血管痉挛、血流速度及神经功能的影响。方法选择2015年6月—2019年6月该院接诊的78例实施蛛网膜下腔出血术的患者进行研究,通过随机数表法分为观察组(n=39)和对照组(n=39),两组术后均给予常规治疗,对照组再给予尼莫地平静脉滴注,观察组联合血塞通注射液静脉滴注。比较两组临床疗效,治疗前后外周血VEGF、sVCAM-1、NF-κB及脑血流速度变化、神经功能评分。结果观察组临床疗效总有效率79.49%明显高于对照组的61.54%,差异有统计学意义(χ2=4.052,P<0.05);治疗后,两组外周血VEGF、sVCAM-1、NF-κB较治疗前均显著升高,差异有统计学意义(P<0.05),观察组均明显低于对照组,差异有统计学意义(P<0.05),且脑血流速度、NIHSS评分均低于对照组,差异有统计学意义(P<0.05)。结论在蛛网膜下腔出血术后使用尼莫地平联合血塞通注射液效果显著,可明显改善脑血流功能,促进神经功能恢复,其内在机制可能与降低外周血VEGF、sVCAM-1、NF-κB的表达相关。Objective To investigate the effect of nimodipine combined with Xuesaitong injection on cerebral vasospasm,blood flow velocity and nerve function after subarachnoid hemorrhage.Methods 78 patients undergoing subarachnoid hemorrhage surgery in the hospital from June 2015 to June 2019 were selected for the study.They were divided into observation group(n=39)and control group(n=39).Both groups were given conventional treatment after operation.The control group was given nimodipine intravenously,and the observation group was given intravenous infusion of Xuesaitong injection.The clinical effects of the two groups were compared,the changes in peripheral blood VEGF,sVCAM-1,NF-κB,cerebral blood flow velocity,and neurological function score before and after treatment.Results The total effective rate of clinical curative effect in the observation group was 79.49%,which was significantly higher than 61.54%in the control group,the difference was statistically significant(χ2=4.052,P<0.05);after treatment,the peripheral blood VEGF,sVCAM-1,and NF-κB in the two groups were significantly higher than before treatment,the difference was statistically significant(P<0.05),the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05),and the cerebral blood flow velocity and NIHSS score were lower than the control group,the difference was statistically significant(P<0.05).Conclusion The use of nimodipine combined with Xuesaitong injection after subarachnoid hemorrhage has a significant effect,which can significantly improve cerebral blood flow function and promote neurological function recovery.Its internal mechanism may reduce peripheral blood VEGF,sVCAM-1,and NF-κB expression related.

关 键 词：蛛网膜下腔出血 尼莫地平 血塞通注射液 血清因子 

分 类 号：R74[医药卫生—神经病学与精神病学]