人乳头状瘤病毒16相关口咽鳞状细胞癌独特生物学行为及治疗的研究现状  

Unique biological behavior and treatment of the human papilloma virus 16-related oropharyngeal squamous cell carcinoma

作　　者：王岳 季一鸣 王晓毅[3] 张凌楠 孙乐刚[1,2] Wang Yue;Ji Yiming;Wang Xiaoyi;Zhang Lingnan;Sun Legang(Dept.of Oral and Maxillofacial Surgery,Affiliated Hospital of Binzhou Medical University,Binzhou 256600,China;School of Stomatology,Binzhou Medical University,Yantai 264010,China;State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Head and Neck Oncology,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;Dept.of Orthodontics,Affiliated Hospital of Binzhou Medical University,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院口腔颌面外科,滨州256600 [2]滨州医学院口腔医学院,烟台264010 [3]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院头颈肿瘤外科,成都610041 [4]滨州医学院附属医院口腔正畸科,滨州256600

出　　处：《国际口腔医学杂志》2021年第4期450-458,共9页International Journal of Stomatology

基　　金：山东省自然科学基金博士基金(ZR2018BH026);山东省医药卫生科技发展计划面上项目(2017WS231);滨州市社会科学规划重点研究课题(19-SKGH-31)。

摘　　要：人乳头状瘤病毒(HPV)感染是口咽鳞状细胞癌(OPSCC)除吸烟、饮酒外第3个独立的致病因素。其中,高危型HPV16在OPSCC发生发展中起着不可替代的重要作用,因HPV16相关OPSCC具有独特的临床病理特征,其预后及治疗方法与其他类型的OPSCC有着明显的不同。在原有治疗方法的基础上,延伸出经口腔内窥镜手术技术、放射和化学治疗、免疫治疗、疫苗预防等更为优良的治疗方法,本文主要围绕HPV16相关OPSCC独特的临床病理特征及治疗方法进行阐述。Human papilloma virus(HPV)infection is the third-largest independent etiological factor causing oropharyngeal squamous cell carcinoma(OPSCC)apart from smoking and drinking.High-risk HPV16 plays an important role in the occurrence and development of OPSCC.Considering its unique clinicopathologic features,the prognosis and treatment methods for HPV16-related OPSCC are significantly different from those for traditional OPSCC.Based on the original treatment methods,transoral endoscopic surgery,radiochemotherapy,immunotherapy,and vaccine treatment are extended.This paper focuses on the unique clinicopathologic features and treatment methods of HPV16-related OPSCC.

关 键 词：人乳头状瘤病毒 口咽鳞状细胞癌 独特临床病理特征 治疗 

分 类 号：R739.8[医药卫生—肿瘤]