153例抗癌药物不良反应报告回顾性分析  

Retrospective analysis of 153 cases of adverse drug reaction reports of anticancer drugs

作　　者：区坚辉 高银 梁刚 OU Jian-hui;GAO Yin;LIANG Gang(Department of Pharmacy,Zhuhai Hospital of Integrated Traditional Chinese&Western Medicine,Zhuhai 519000,China;不详)

机构地区：[1]珠海市中西医结合医院,广东珠海519000 [2]西南医科大学附属中医医院磁共振室,四川泸州646000 [3]西南医科大学附属中医医院采购供应部,四川泸州646000

出　　处：《中国处方药》2021年第6期52-54,共3页Journal of China Prescription Drug

摘　　要：目的分析医院抗癌药物不良反应(adverse drug reaction,ADR)的发生规律与特点,为临床安全使用抗癌药物提供参考。方法抽取某院2017~2019年上报至国家药品不良反应监测系统的抗癌药物ADR共153例,分析患者的性别、年龄、原患疾病、给药途径、药品种类、受累系统/器官、临床表现、联合用药与ADR的关系,以及ADR的程度、转归及关联性评价。结果153例抗癌药物ADR中,男10例(6.54%),女143例(6.54%);45~64岁年龄段例次最多,为99例(64.71%)。因乳腺癌使用抗癌药物的患者最多,131例(85.62%)。静脉给药引发ADR最多,146例(95.42%)。注射用盐酸表柔比星为ADR报告数最多的品种,48例(31.37%)。消化系统为最常见受累器官/系统,102例(48.34%),白细胞减少为最常见症状,71例(33.65%)。一般反应101例(66.01%),新的一般反应6例(3.92%),严重45例(29.41%),新的严重1例(0.65%)。联合用药91例(59.48%)。结论临床应加强抗癌药物使用过程中的用药监护,预防和减少ADR的发生,对已发生的及时治疗并上报,竭力提高癌症患者的生存和生活质量。Objective To analyze the regularity and characteristics of ADR in hospitals,so as to provide reference for the safe use of anticancer drugs in clinic.Methods A total of 153 anticancer drug ADRs reported by a hospital to the National ADR monitoring system from 2017 to 2019 were selected to analyze the relationship between gender,age,original disease,route of administration,type of drug,involved system/organ,clinical manifestations,combination of drugs and ADRS,as well as the degree,outcome and correlation evaluation of ADRO.Results Among the 153 cases of anticarcinogen ADRs,10 case(s 6.54%)were male,170 cases(93.46%)were female,and the most cases occurred in the 45~64 years old age group,99 cases(64.71%).Breast cancer was the most common cause of cancer drug use,131 cases(85.62%).Intravenous administration was the main way to induce ADR,146 cases(95.42%).Epirubicin hydrochloride for injection was the most frequently reported ADR,48 cases(31.37%).The digestive system was the most common organ/system involved in ADR,102 cases(48.34%),and leukopenia was the most common symptom,71 cases(33.65%).There were 101 cases(66.01%)with general ADR,6 cases(66.01%)with new general ADR,45 cases(29.41%)with severe ADR and 1 case(0.65%)with nes severe ADR,91 cases(59.48%)ADR were caused by combined drugs.Conclusion It is necessary to strengthen the monitoring of anticancer drugs in clinical practice,prevent and reduce the occurrence of ADR,timely treat and report the occurrence of ADR,and try to improve the survival and quality of life of cancer patients.

关 键 词：抗癌药物 药品不良反应报告 分析 安全用药 

分 类 号：R95[医药卫生—药学]