局部不可切除胃癌的转化治疗(附10例报告)  

Transformation Therapy for Locally Unresectable Gastric Cancer(10 Cases Report)

作　　者：肖俊峰 王昌青[1] 王贵和[1] XIAO Jun-feng;WANG Chang-qing;WANG Gui-he(Department of Gastroenterology, Tongling People's Hospital, Tongling 244000, Anhui, China)

机构地区：[1]安徽省铜陵市人民医院胃肠外科,安徽铜陵244000

出　　处：《中国现代手术学杂志》2021年第2期101-104,共4页Chinese Journal of Modern Operative Surgery

摘　　要：目的总结胃癌转化治疗的治疗经验,探讨其疗效及安全性。方法回顾性分析铜陵市人民医院2014年1月至2020年3月收治的10例胃癌转化治疗的临床资料。结果5例部分缓解(partial remissision,PR),其余为疾病稳定(stable disease,SD)。肿瘤退缩分级:0级2例,1级及2级各1例,3级3例,3例腹腔镜探查时发现16组淋巴结转移,未予切除。化疗反应:Ⅰ级骨髓抑制5例,Ⅰ~Ⅱ级胃肠道反应6例,术后1例出现十二指肠残端漏伴腹腔内出血,经保守治疗后康复出院。结论对于有适应证的局部不可切除胃癌患者,胃癌转化治疗是有效且安全的。Objective To conclude the experiences of the gastric cancer transformation therapy for locally unresectable gastric cancer patients.Methods The clinical data of 10 patients with locally unresectable gastric cancer received transformation therapy in our hospital from January 2014 to March 2020 were retrospectively analyzed.Results 5 cases showed partial remission(PR),and the other 5 cases were stable disease(SD).The grade of tumor regression was grade 0 in 2 cases,grade 1 in 1 case,grade 2 in 1 case and grade 3 in 3 cases.Laparoscopic exploration was performed only in 3 cases because of lymph node metastasis in the 16th groups.There were 5 cases with gradeⅠmyelosuppression,and 6 cases with gradeⅠ~Ⅱgastrointestinal reaction during the chemotherapy.One case had duodenal stump leakage and intra-abdominal hemorrhage after operation,and was cured by conservative treatments.Conclusion Gastric cancer transformation therapy is effective and safe for locally unresectable gastric cancer patients with indications.

关 键 词：胃肿瘤 转化治疗 局部晚期 

分 类 号：R735.2[医药卫生—肿瘤]