Recent advances in drug delivery applications of cubosomes,hexosomes,and solid lipid nanoparticles  

作　　者：Anan Yaghmur Huiling Mu 

机构地区：[1]Department of Pharmacy,Faculty of Health and Medical Sciences,University of Copenhagen,Universitetsparken 2,CopenhagenФ2100,Denmark

出　　处：《Acta Pharmaceutica Sinica B》2021年第4期871-885,共15页药学学报（英文版）

基　　金：Financial support to Anan Yaghmur for studies on development of drug nanocarriers based on cubosomes and hexosomes by the Danish Council for Independent Research|Technology and Production Sciences(references 1335-00150b and DFF-7017-00065,Denmark)。

摘　　要：The use of lipid nanocarriers for drug delivery applications is an active research area,and a great interest has particularly been shown in the past two decades.Among different lipid nanocarriers,ISAsomes(Internally self-assembled somes or particles),including cubosomes and hexosomes,and solid lipid nanoparticles(SLNs)have unique structural features,making them attractive as nanocarriers for drug delivery.In this contribution,we focus exclusively on recent advances in formation and characterization of ISAsomes,mainly cubosomes and hexosomes,and their use as versatile nanocarriers for different drug delivery applications.Additionally,the advantages of SLNs and their application in oral and pulmonary drug delivery are discussed with focus on the biological fates of these lipid nanocarriers in vivo.Despite the demonstrated advantages in in vitro and in vivo evaluations including preclinical studies,further investigations on improved understanding of the interactions of these nanoparticles with biological fuids and tissues of the target sites is necessary for effcient designing of drug nanocarriers and exploring potential clinical applications.

关 键 词：Biological fate CUBOSOMES Drug delivery Hexosomes Inverse non-lamellar liquid crystalline phases Nano-self-assemblies Solid crystalline phases Solid lipid nanoparticles 

分 类 号：R943[医药卫生—药剂学] TQ460.4[医药卫生—药学] TB383.1[化学工程—制药化工]