肺癌脑转移患者肺组织中TIMP3、SDF1水平与临床病理特征及预后关系  

Relationships between the levels of TIMP3 and SDF1 in lung tissue and clinicopathological features, prognosis in patients with brain metastasis of lung cancer

作　　者：李德生[1] 井晓亮 张力为[1] 杨凡 孙清超[1] 宗亮[1] 居来提·艾尼瓦尔[1] LI De-sheng;JING Xiao-liang;ZHANG Li-wei(Department of Thoracic Surgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi Xinjiang 830054,China)

机构地区：[1]新疆医科大学第一附属医院胸外科,新疆乌鲁木齐830054 [2]新疆阿克苏地区第二人民医院胸外科,新疆阿克苏843000

出　　处：《临床和实验医学杂志》2021年第11期1163-1167,共5页Journal of Clinical and Experimental Medicine

基　　金：省部共建中亚高发病成因与防治国家重点实验室开放课题资助项目资助(编号:SKL-HIDCA-2020-42)。

摘　　要：目的通过检测肺癌脑转移患者肺组织中金属蛋白酶组织抑制因子3(TIMP3)、基质细胞衍生因子1(SDF1)水平,分析两者与临床病理特征及患者预后关系。方法回顾性选取2015年5月至2020年5月新疆医科大学第一附属医院收治的肺癌脑转移患者83例,肺癌未脑转移患者83例。术中收集入组脑转移患者、未脑转移患者和癌旁(距病灶>5 cm)肺组织。免疫组化染色法检测TIMP3、SDF1蛋白表达水平,并分析两者与临床病理特征及患者预后关系。结果TIMP3蛋白在肺癌脑转移组、未脑转移组及癌旁肺组织中阳性表达率(28.92%、48.19%、69.88%)依次显著升高(P<0.05),SDF1蛋白在肺癌脑转移组、未脑转移组及癌旁肺组织中阳性表达率(74.70%、56.63%、36.14%)依次显著降低(P<0.05)。肺癌脑转移组患者肺组织中TIMP3、SDF1水平与脑转移灶数目、分化程度和淋巴结转移有关(P<0.05)。TIMP3与SDF1蛋白在肺癌脑转移患者肺组织中表达水平呈负相关(r=-0.423,P<0.05)。TIMP3阴性表达患者1年总生存率为30.51%,显著低于TIMP3阳性表达患者,差异有统计学意义(P<0.05)。TIMP3阴性表达患者1年总生存率(30.51%)明显低于TIMP3阳性表达患者(54.17%)(P<0.05),SDF1阴性表达患者1年总生存率(57.14%)明显高于SDF1阳性表达患者(30.65%)(P<0.05)。多发脑转移灶、淋巴结转移、TIMP3阴性及SDF1阳性是影响肺癌脑转移患者预后独立危险因素(P<0.05)。结论TIMP3、SDF1蛋白阳性表达率在肺癌脑转移患者肺组织分别呈低表达与高表达,可能用于预测患者预后,对改善预后意义重大。Objective To analyze the relationships between tissue inhibitor of metalloproteinase 3(TIMP3),stromal cell derived factor 1(SDF1)levels in lung tissue and clinicopathological characteristics,prognosis of patients with brain metastasis from lung cancer by detecting their expression levels.Methods From May 2015 to May 2020,83 patients with brain metastasis lung cancer and 83 patients without brain metastasis lung cancer were selected.Lung cancer tissues from patients with brain metastasis,lung cancer tissues and adjacent tissues(from lesions>5 cm)from patients without brain metastasis were collected during operation.Immunohistochemical staining was used to detect the expressions of TIMP3 and SDF1,and the relationships between them and clinicopathological characteristics,prognosis were analyzed.Results The positive expression rate of TIMP3 protein in lung cancer tissues in brain metastasis group of lung cancer,lung cancer tissues and adjacent tissues in non-brain metastasis group(28.92%,48.19%,69.88%)increased significantly in turn(P<0.05),while the positive expression rate of SDF1 protein in lung cancer tissues in brain metastasis group of lung cancer,lung cancer tissues and adjacent tissues in non-brain metastasis group(74.70%、56.63%、36.14%)decreased significantly in turn(P<0.05).The levels of TIMP3 and SDF1 in lung cancer tissues of patients with brain metastasis of lung cancer were related to the number of brain metastases,degree of differentiation and lymph node metastasis(P<0.05).There was a negative correlation between the expressions of TIMP3 and SDF1 proteins in lung tissues of patients with brain metastasis of lung cancer(r=-0.423,P<0.05).The 1-year overall survival rate of patients with negative expression of TIMP3(30.51%)was significantly lower than that of patients with positive expression of TIMP3(54.17%)(P<0.05),and the 1-year overall survival rate of patients with negative expression of SDF1(57.14%)was significantly higher than that of patients with positive expression of SDF1(30.65%)(P<0.05).Mul

关 键 词：肺癌脑转移 金属蛋白酶组织抑制因子3 基质细胞衍生因子1 临床病理特征 预后 

分 类 号：R734.2[医药卫生—肿瘤]