电视胸腔镜治疗对纵隔肿瘤患者致痛因子BK、NPY以及5-HT的影响  

Effects of video-assisted thoracoscopic surgery on pain factors BK, NPY and 5-HT in patients with mediastinal tumor

作　　者：余俊隆 郝瑞[1] 向秋 房渝[2] YU Jun-long;HAO Rui;XIANG Qiu(Department of Thoracic Surgery,Yibin First People's Hospital,Yibin Sichuan 644000,China)

机构地区：[1]宜宾市第一人民医院胸外科,四川宜宾644000 [2]重庆医科大学附属第一医院胸心外科,重庆400042

出　　处：《临床和实验医学杂志》2021年第11期1188-1191,共4页Journal of Clinical and Experimental Medicine

基　　金：国家自然科学基金青年基金项目(编号:81400590)。

摘　　要：目的探讨电视胸腔镜治疗对纵隔肿瘤患者致痛因子缓激肽(BK)、脑内神经肽-Y(NPY)和5-羟色胺(5-HT)水平影响,并总结治疗相关并发症的发生情况。方法回顾性分析2018年6月至2020年6月期间宜宾市第一人民医院收治的94例纵隔肿瘤患者资料,依据术式不同将其分为对照组(n=47)与研究组(n=47),对照组给予患者行传统开胸手术治疗,研究组予以患者电视胸腔镜外科术式(VATS)治疗。比较2组患者手术时间、术中出血量、开胸以及关胸时间,并比较2组患者血浆中致痛因子BK、NPY以及5-HT水平变化,同时统计并发症发生情况。结果研究组患者手术时间为(144.68±31.58)min,与对照组[(147.33±30.29)min]比较,差异无统计学意义(P>0.05)。研究组患者的术中出血量为(86.78±9.46)mL,明显少于对照组[(126.54±10.47)mL];开胸时间、关胸时间分别为(12.89±3.66)、(12.21±2.09)min,均明显短于对照组[(18.97±4.04)、(21.03±3.88)min],差异均有统计学意义(P<0.05)。术后第1天,研究组患者血浆中BK、NPY以及5-HT水平分别为(8.15±0.57)μg/L、(201.81±20.30)μg/L、(187.41±17.50)ng/L,均明显低于对照组[(11.58±1.39)μg/L、(248.55±24.61)μg/L、(227.94±25.64)ng/L],差异均有统计学意义(P<0.05)。研究组患者的总并发症发生率4.26%,明显低于对照组的21.28%,差异有统计学意义(P<0.05)。结论VATS治疗纵隔肿瘤,可以显著降低相关致痛因子的分泌水平,缓解患者疼痛且能够明显降低患者并发症发生率,有助术后恢复。Objective To investigate the effect of video-assisted thoracoscopic treatment on the levels of pain-causing factors bradykinin(BK),neuropeptide-Y(NPY)and serotonin(5-HT)in patients with mediastinal tumors,and summarize the treatment-related complications What happened.Methods A retrospective analysis of the data of 94 mediastinal tumor patients who met the inclusion and exclusion criteria admitted to the Yibin First People's Hospital from June 2018 to June 2020 were divided into control groups according to different surgical procedures(n=47)and the study group(n=47),the control group was treated with traditional thoracotomy;the study group was treated with video-assisted thoracoscopic surgery(VATS)to compare the operation time and intraoperative blood loss between the two groups,Chest opening and closing time,and compare the changes in the levels of pain-causing factors BK,NPY and 5-HT between the two groups,and also count the occurrence of complications.Results The operation time of the patients in the study group was(144.68±31.58)min,which was not statistically different compared with(147.33±30.29)min in the control group(P>0.05).The intraoperative blood loss of the study group was(86.78±9.46)mL,which was significantly less than that of the control group(126.54±10.47)mL;the time to open the chest and the time to close the chest were(12.89±3.66),(12.21±2.09)min,which were significantly shorter than those of the control group(18.97±4.04),(21.03±3.88)min,the differences were statistically significant(P<0.05).On the first day after surgery,the levels of BK,NPY,and 5-HT in the study group were(8.15±0.57)μg/L,(201.81±20.30)μg/L,and(187.41±17.50)ng/L,respectively,which were all significantly lower than those of the control group(11.58±1.39)μg/L,(248.55±24.61)μg/L,(227.94±25.64)ng/L,the differences were statistically significant(P<0.05).The total incidence of complications in the study group was 4.26%,which was significantly lower than the control group 21.28%,and the difference was statistically sign

关 键 词：纵隔肿瘤 电视胸腔镜 传统开胸手术 致痛因子 并发症 

分 类 号：R734.5[医药卫生—肿瘤]