首发儿童青少年抑郁障碍患者静息态双侧杏仁核功能连接异常  

Abnormal functional connectivity of bilateral amygdala at resting-state in first-episode of childhoodand adolescent patients with depressive disorder

作　　者：辛博[1] 王朝敏[1] 李娜[1] 余明[1] 郭新字[1] 王蒙 刘前莉 刘艳菊[1] 刘春梅[1] 刘虹 Xin Bo;Wang Chaomin;Li Na;Yu Ming;Guo Xinzi;Wang Meng;Liu Qianli;Liu Yanju;Liu Chunmei;Liu Hong(Department of Mental Health,the First Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第一医院精神卫生科,石家庄050000

出　　处：《神经疾病与精神卫生》2021年第6期400-403,共4页Journal of Neuroscience and Mental Health

基　　金：河北省卫健委医学科学研究课题(20201154)。

摘　　要：目的采用静息态功能磁共振成像技术探讨首发儿童青少年抑郁障碍患者左右杏仁核与全脑功能连接特点,并分析异常功能连接与抑郁症状的相关性。方法选取2015年10月至2019年6月就诊于河北医科大学第一医院精神卫生中心的21例门诊和住院首发儿童青少年抑郁障碍患者作为患者组,选取20名健康儿童青少年作为对照组,均接受静息状态功能磁共振扫描。以左右杏仁核为感兴趣脑区进行全脑功能连接分析,比较两组间的功能连接差异;采用24项汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD-24)评估患者组抑郁症状的严重程度,并进一步分析抑郁症状与左右杏仁核功能连接的相关性。结果与对照组相比,患者组的右侧杏仁核与右侧额上回、左侧额上回、右侧颞中回功能连接降低(t=-4.49、-4.54、-4.91,GRF校正,均P<0.05),左侧杏仁核与右侧楔前叶、左侧背外侧前额叶功能连接降低(t=-6.40、-5.51,GRF校正,均P<0.05);右侧杏仁核与右侧颞中回之间的功能连接与HAMD-24评分呈负相关(r=-0.920,P<0.05,Bonferroni校正)。结论静息态下首发儿童青少年抑郁障碍患者左右杏仁核功能连接异常,且右侧杏仁核与右侧颞中回之间降低的功能连接与抑郁症状的严重程度相关。Objective To explore the functional connection characteristics of left and right amygdala in first-episode of childhood and adolescent patients with depressive disorder by rest state functional magnetic resonance imaging,and to analyze the correlation between abnormal functional connectivity and depressive symptoms.Methods From Octorber 2015 to June 2019,a total of 21 outpatients and inpatients with firstepisode childhood and adolescent depressive disorder in Mental Health Center of the First Hospital of Hebei Medical University were selected as the patient group,and 20 healthy children and adolescents were recruited as the control group.All the subjects were scanned by resting-state functional magnetic resonance imaging(fMRI).The left and right amygdalas were used as the brain regions of interest for the whole brain functional connectivity analysis to compare the functional connectivity differences between the two groups.The 24-item Hamilton Depression Scale(HAMD-24)was used to evaluate the severity of depressive symptoms of the patient group,so as to analyze the correlation between depressive symptoms and functional connectivity of left and right amygdala.Results Compared with the controls group,the functional connections between the right amygdala and right superior frontal gyrus,left superior frontal gyrus,right middle temporal gyrus were reduced(t=-4.49,-4.54,-4.91,GRF corrected,all P<0.05);the functional connections between the left amygdala and right precuneus,left dorsolateral prefrontal lobe were reduced(t=-6.40,-5.51,GRF corrected,all P<0.05).The functional connectivity between the right amygdala and the right middle temporal gyrus were negatively correlated with the HAMD-24 score(r=-0.920,P<0.05,Bonferroni corrected).Conclusions The abnormal functional connectivity of bilateral amygdala at resting-state in first-episode of childhood and adolescent patients with depressive disorder and the decreased functional connectivity between the right amygdala and the right middle temporal gyrus are related to the

关 键 词：抑郁障碍 儿童 青少年 杏仁核 功能连接 

分 类 号：R749.4[医药卫生—神经病学与精神病学]